Activity of Antimicrobial Combinations against KPC-2-Producing Klebsiella pneumoniae in a Rat Model and Time-Kill Assay

被引：28
|
作者：
Michelon Toledo, Paula Virginia [1 ,2 ]
Aranha Junior, Ayrton Alves [2 ,3 ]
Arend, Lavinia Nery [4 ]
Ribeiro, Vanessa [5 ]
Zavascki, Alexandre Prehn [5 ]
Tuon, Felipe Francisco [1 ,6 ]
机构：
[1] Univ Fed Parana, Internal Med Postgrad Training, BR-80060000 Curitiba, Parana, Brazil
[2] Univ Estadual Ponta Grossa, Dept Med, Ponta Grossa, Brazil
[3] Univ Fed Parana, Dept Anat, BR-80060000 Curitiba, Parana, Brazil
[4] Bacteriol Sect, Lab Cent Saude Publ Estado LACEN PR, Curitiba, Parana, Brazil
[5] Hosp Clin Porto Alegre, Infect Dis Serv, Porto Alegre, RS, Brazil
[6] Hosp Univ Evangel Curitiba, Div Infect & Parasit Dis, Curitiba, Parana, Brazil
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 07期
关键词：
POLYMYXIN-B; TIGECYCLINE; INFECTIONS; MEROPENEM; MORTALITY; EFFICACY; GLYCYLCYCLINE; GENTAMICIN; PREDICTORS; BACTEREMIA;
D O I：
10.1128/AAC.00323-15
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
This study evaluated the efficacy of tigecycline (TIG), polymyxin B (PMB), and meropenem (MER) in 80 rats challenged with Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae infection. A time-kill assay was performed with the same strain. Triple therapy and PMB + TIG were synergistic, promoted 100% survival, and produced negative peritoneal cultures, while MER + TIG showed lower survival and higher culture positivity than other regimens (P = 0.018) and was antagonistic. In vivo and in vitro studies showed that combined regimens, except MER + TIG, were more effective than monotherapies for this KPC-producing strain.
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页码：4301 / 4304
页数：4
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