Iridium(III)-Catalyzed B(4)-Acylmethylation and B(3,5)-Diacylmethylation from o-Carboranes and Sulfoxonium Ylides

被引：18
|
作者：
Ko, Gi Hoon [1 ]
Um, Kyusik [1 ,2 ]
Noh, Hee Chan [1 ]
Kim, Jin Young [1 ]
Jeong, Haneal [1 ]
Maeng, Chanyoung [1 ]
Han, Sang Hoon [1 ]
Han, Gi Uk [1 ]
Lee, Phil Ho [1 ,2 ]
机构：
[1] Kangwon Natl Univ, Dept Chem, Chunchon 24341, South Korea
[2] Kangwon Natl Univ, KIIT Kangwon Inst Inclus Technol, Chunchon 24341, South Korea
来源：
ORGANIC LETTERS | 2022年 / 24卷 / 08期
基金：
新加坡国家研究基金会;
关键词：
CAGE B-H; BORON CLUSTERS; BONDS; PHARMACOPHORES; ALKENYLATION; ACTIVATION; CHEMISTRY;
D O I：
10.1021/acs.orglett.2c00103
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An iridium(III)-catalyzed regioselective acylmethylation of the cage B(4)-H bond in o-carborane acids with sulfoxonium Aides is demonstrated through B(4)-H activation in ethanol under very mild conditions, affording a number of B(4)-acylmethylated o-carboranes. Additionally, the selective sequential B(4)- and B(6)-acylmethylation reactions finally gave B(3,5)-diacylmethylated o-carboranes in one pot.
引用
收藏
页码：1604 / 1609
页数：6
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