Iridium(III)-Catalyzed B(4)-Acylmethylation and B(3,5)-Diacylmethylation from o-Carboranes and Sulfoxonium Ylides

被引：18

作者：

Ko, Gi Hoon ^{[1
]}

Um, Kyusik ^{[1
,2
]}

Noh, Hee Chan ^{[1
]}

Kim, Jin Young ^{[1
]}

Jeong, Haneal ^{[1
]}

Maeng, Chanyoung ^{[1
]}

Han, Sang Hoon ^{[1
]}

Han, Gi Uk ^{[1
]}

Lee, Phil Ho ^{[1
,2
]}

机构：

[1] Kangwon Natl Univ, Dept Chem, Chunchon 24341, South Korea

[2] Kangwon Natl Univ, KIIT Kangwon Inst Inclus Technol, Chunchon 24341, South Korea

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

CAGE B-H; BORON CLUSTERS; BONDS; PHARMACOPHORES; ALKENYLATION; ACTIVATION; CHEMISTRY;

D O I：

10.1021/acs.orglett.2c00103

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An iridium(III)-catalyzed regioselective acylmethylation of the cage B(4)-H bond in o-carborane acids with sulfoxonium Aides is demonstrated through B(4)-H activation in ethanol under very mild conditions, affording a number of B(4)-acylmethylated o-carboranes. Additionally, the selective sequential B(4)- and B(6)-acylmethylation reactions finally gave B(3,5)-diacylmethylated o-carboranes in one pot.

引用

页码：1604 / 1609

页数：6

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