Important molecular genetic markers of colorectal cancer

被引：82

作者：

Kudryavtseva, Anna V. ^{[1
,2
]}

Lipatova, Anastasia V. ^{[1
]}

Zaretsky, Andrew R. ^{[3
]}

Moskalev, Alexey A. ^{[1
]}

Fedorova, Maria S. ^{[1
,2
]}

Rasskazova, Anastasiya S. ^{[1
]}

Shibukhova, Galina A. ^{[2
]}

Snezhkina, Anastasiya V. ^{[1
]}

Kaprin, Andrey D. ^{[2
]}

Alekseev, Boris Y. ^{[2
]}

Dmitriev, Alexey A. ^{[1
]}

Krasnov, George S. ^{[1
,4
]}

机构：

[1] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow, Russia

[2] Minist Healthcare Russian Federat, Natl Med Res Radiol Ctr, Moscow, Russia

[3] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow, Russia

[4] Russian Acad Med Sci, Orekhovich Inst Biomed Chem, Moscow, Russia

来源：

ONCOTARGET | 2016年 / 7卷 / 33期

基金：

俄罗斯科学基金会;

关键词：

colorectal cancer; molecular markers; chromosomal instability; microsatellite instability; CpG island methylator phenotype; ISLAND METHYLATOR PHENOTYPE; OXALIPLATIN-BASED CHEMOTHERAPY; MESSENGER-RNA EXPRESSION; POPULATION-BASED SERIES; APC TUMOR-SUPPRESSOR; AURORA-A EXPRESSION; NF-KAPPA-B; MICROSATELLITE-INSTABILITY; COLON-CANCER; CHROMOSOMAL INSTABILITY;

D O I：

10.18632/oncotarget.9796

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) ranks third in the incidences of cancer morbidity and mortality worldwide. CRC is rather heterogeneous with regard to molecular genetic characteristics and pathogenic pathways. A wide spectrum of biomarkers is used for molecular subtype determination, prognosis, and estimation of sensitivity to different drugs in practice. These biomarkers can include germline and somatic mutations, chromosomal aberrations, genomic abnormalities, gene expression alterations at mRNA or protein level and changes in DNA methylation status. In the present review we discuss the most important and well-studied CRC biomarkers, and their potential clinical significance and current approaches to molecular classification of colorectal tumors.

引用

页码：53959 / 53983

页数：25

共 50 条

[21] Molecular markers and targets for colorectal cancer prevention
Naveena B Janakiram
Chinthalapally V Rao
Acta Pharmacologica Sinica, 2008, 29 : 1 - 20
[22] Molecular Markers of Chemotherapy Response in Colorectal Cancer
Braun, Michael S.
Seymour, Matthew T.
CURRENT COLORECTAL CANCER REPORTS, 2010, 6 (03) : 118 - 125
[23] Fecal Molecular Markers for Colorectal Cancer Screening
Kanthan, Rani
Senger, Jenna-Lynn
Kanthan, Selliah Chandra
GASTROENTEROLOGY RESEARCH AND PRACTICE, 2012, 2012
[24] A Panel of Prognostic Molecular Markers in Colorectal Cancer
Ivanov, K.
Kolev, N.
Tonev, A.
Nikolova, G.
Softova, E.
PROCEEDINGS OF THE XXII BIENNIAL CONGRESS OF THE INTERNATIONAL SOCIETY OF UNIVERSITY COLON AND RECTAL SURGEONS - ISUCRS, 2008, : 51 - +
[25] Molecular Markers of Chemotherapy Toxicity in Colorectal Cancer
Braun, Michael S.
Seymour, Matthew T.
CURRENT COLORECTAL CANCER REPORTS, 2011, 7 (01) : 105 - 111
[26] Therapeutic relevance of molecular markers in colorectal cancer
Noepel-Duennebacke, Stefanie
Conradi, Lena-Christin
Reinacher-Schick, Anke
Ghadimi, Michael
ONKOLOGE, 2020, 26 (08): : 685 - 697
[27] Molecular Markers in the Treatment of Metastatic Colorectal Cancer
Wilson, Peter M.
LaBonte, Melissa J.
Lenz, Heinz-Josef
CANCER JOURNAL, 2010, 16 (03): : 262 - 272
[28] Molecular genetic phenotypes of colorectal cancer
Tatiana, K.
ANNALS OF ONCOLOGY, 2024, 35 : S69 - S69
[29] Molecular genetic markers of economically important traits in dairy cattle
Yudin, N. S.
Voevoda, M. I.
RUSSIAN JOURNAL OF GENETICS, 2015, 51 (05) : 506 - 517
[30] Molecular genetic markers of economically important traits in dairy cattle
N. S. Yudin
M. I. Voevoda
Russian Journal of Genetics, 2015, 51 : 506 - 517

← 1 2 3 4 5 →