Age factor and implication of human papillomavirus type-specific prevalence in women with normal cervical cytology

被引：8
|
作者：
Lai, C. H. [1 ,2 ]
Chao, A. [2 ]
Chang, C. J. [3 ]
Huang, C. C. [2 ]
Wang, L. C. [2 ]
Hsueh, S. [2 ,4 ]
Lin, C. T. [2 ]
Wu, T. I. [2 ]
Jao, M. S. [2 ]
Chou, H. H. [2 ]
机构：
[1] Chang Gung Mem Hosp, Linkou Med Ctr, Dept Obstet & Gynecol, Tao Yuan 333, Taiwan
[2] Chang Gung Univ, Coll Med, Tao Yuan, Taiwan
[3] Chang Gung Univ, Grad Inst Clin Med Sci, Tao Yuan, Taiwan
[4] Chang Gung Mem Hosp, Dept Pathol, Tao Yuan, Taiwan
来源：
EPIDEMIOLOGY AND INFECTION | 2012年 / 140卷 / 03期
关键词：
Age; cohort; human papillomavirus; normal cytology; prevalence; REPUBLIC-OF-CHINA; HPV INFECTION; PAP-SMEAR; CANCER; DNA; PERSISTENCE; GENOTYPE; HISTORY; RISK;
D O I：
10.1017/S0950268811000720
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The prevalence and genotype distribution of human papillomavirus (HPV) infection in women with normal cervical cytology varies widely according to the population studied. Two non-overlapping population-based cohort studies of women aged >= 30 years for the periods 2008-2009 (n = 5026) and 2004-2005 (n = 10 014) were analysed. The prevalence rate of HPV was 11.0% (95% CI 10.5-11.6). HPV infection was significantly associated with age, menopausal status, and inversely associated with hormone replacement therapy. There was an increasing trend of alpha 3/alpha 15, alpha 5/alpha 6, and multiple HPV infections with increasing age. The five most common types were HPV52, 18, 53, 58 and 70, while HPV16, 31, 33 ranked 21st, 25th, and 16th, respectively, in the merged cohort with normal cytology (n = 14 724). HPV16, 31, and 33 were significantly associated with abnormal cytology, which could have resulted in their rarity in the total merged cohort (n = 15 040).
引用
收藏
页码：466 / 473
页数：8
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