Totopotensamides, Polyketide-Cyclic Peptide Hybrids from a Mollusk-Associated Bacterium Streptomyces sp.

被引：23

作者：

Lin, Zhenjian ^{[1
]}

Flores, Malem ^{[2
]}

Forteza, Imelda ^{[2
]}

Henriksen, Niel M. ^{[1
]}

Concepcion, Gisela P. ^{[2
]}

Rosenberg, Gary ^{[3
]}

Haygood, Margo G. ^{[4
]}

Olivera, Baldomero M. ^{[5
]}

Light, Alan R. ^{[6
]}

Cheatham, Thomas E., III ^{[1
]}

Schmidt, Eric W. ^{[1
,5
]}

机构：

[1] Univ Utah, Coll Pharm, Salt Lake City, UT 84112 USA

[2] Univ Philippines, Inst Marine Sci, Quezon City 1101, Philippines

[3] Acad Nat Sci Philadelphia, Philadelphia, PA 19103 USA

[4] Oregon Hlth & Sci Univ, Dept Environm & Biomol Syst, OGI Sch Sci & Engn, Beaverton, OR 97006 USA

[5] Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA

[6] Univ Utah, Dept Anesthesiol, Salt Lake City, UT 84112 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 04期

关键词：

CONSTITUENT AMINO-ACIDS; ABSOLUTE-CONFIGURATION; MARFEYS METHOD; METABOLITES; LC/MS;

D O I：

10.1021/np200886x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new compounds, the peptide polyketide glycoside totopotensamide A (1) and its aglycone totopotensamide B (2), were isolated from a Streptomyces sp. cultivated from the gastropod mollusk Lienardia totopotens collected in the Philippines. The compounds contain a previously undescribed polyketide component, a novel 2,3-diaminobutyric acid-containing macrolactam, and a new amino acid, 4-chloro-5,7-dihydroxy-6-methylphenylglycine. The application of Marfey's method to phenylglycine derivatives was explored using quantum mechanical calculations and NMR.

引用

页码：644 / 649

页数：6

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