Bone mineral metabolism in children with biliary atresia after living related liver transplantation. Evaluation of selected parameters

Background: Aim of the study was to analyze die effect of living related liver transplantation on selected parameters of bone formation and resorption in children with liver cirrhosis caused by biliary atresia. Material/Methods: 20 children (13F/7M) with biliary atresia aged from 6 month to 2.4 years were enrolled into die study 4-9 (lays before liver transplantation. Osteocalcin, procollagen 1 aminoterminal propeptide, collagen type 1 crosslinked C-telopeptide, parathyroid hormone and metabolites of vitamin D: 25 (OH) D-3, 1,25 (OH)(2)D-3 were measured before, 3, 6 and 12 months after liver transplantation. Results: Three months after living related liver transplantation statistically significant increase of osteocalcin, collagen type 1 crosslinked C-telopeptide, parathyroid hormone and 1,25 (OH)(2)D-3 levels were found. We didn't observe further increase of these parameters during the next 9 months after liver transplantation. There was no difference in 25(OH)D-3 levels in patients before and after liver transplantation. Conclusions: In children after successful living related liver transplantation we observed improvement. of selected parameters of bone formation and resorption winch indicate stimulation of growing processes and mechanism of bone geometry modelling.