Biliary bacterial infection decreased the secretion of bile acids and bilirubin into bile

被引:6
|
作者
Nishida, T
Nakahara, M
Nakao, K
Matsuda, H
机构
[1] Osaka Univ, Sch Med, Dept Surg 1, Osaka 5650781, Japan
[2] Osaka Police Hosp, Dept Surg, Osaka, Japan
来源
AMERICAN JOURNAL OF SURGERY | 1999年 / 177卷 / 01期
关键词
D O I
10.1016/S0002-9610(98)00291-8
中图分类号
R61 [外科手术学];
学科分类号
摘要
BACKGROUND: Bacterial cholangitis is frequently associated with serious complications. METHODS: The plasma disappearance rates and the biliary output of bile acids and bilirubin after percutaneous transhepatic biliary drainage (PTBD) were examined in 29 patients with extrahepatic biliary obstruction. RESULTS: Twenty-nine patients were divided into the bacteria-minus (n = 17) and bacteria-plus (n = 12) groups. Decreases in the plasma bile acid and bilirubin levels of the bacteria-minus group (t(1/2) = 0.38 and 3.8 days for bile acids and bilirubin, respectively) were faster than those of the bacteria-plus group (t(1/2) = 1.7 and 7.5 days). The bile flow rate was significantly increased in the bacteria-plus group compared with the bacteria-minus group. The calculated values of bilirubin and bile acid in the bile were higher in the bacteria-minus group than in the bacteria-plus group. CONCLUSIONS: Bacterial colonization in the bile stimulates bile duct cells to increase bile volume and inhibits the hepatocyte transport activity of bile acids and bilirubin. Am J Surg. 1999;177: 38-41. (C) 1999 by Excerpta Medica, Inc.
引用
收藏
页码:38 / 41
页数:4
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