C,O-Chelated organotin(IV) derivatives as potential anticancer agents: Synthesis, characterization, and cytotoxic activity

被引:13
|
作者
Somesan, Adrian-Alexandru [1 ]
Vieriu, Sabina-Madalina [1 ]
Craciun, Alexandru [1 ]
Silvestru, Cristian [1 ]
Chiroi, Paul [2 ]
Nutu, Andreea [2 ]
Jurj, Ancuta [2 ]
Lajos, Raduly [2 ]
Berindan-Neagoe, Ioana [2 ]
Varga, Richard A. [1 ]
机构
[1] Babes Bolyai Univ, Supramol Organ & Organometall Chem Ctr, Dept Chem & Chem Engn, 11 Arany Janos, RO-400028 Cluj Napoca, Romania
[2] Iuliu Hatieganu Univ Med & Pharm, Res Ctr Funct Genom Biomed & Translat Med, Cluj Napoca, Romania
关键词
Sn-119 NMR spectroscopy; C; O-ligands; cytotoxic activity; organotin(IV); structural investigation; IN-VITRO; STRUCTURAL-CHARACTERIZATION; CARBOXYLATE COMPLEXES; MOLECULAR-STRUCTURES; LIGANDS; SYNTHESIS; ARYLTIN CHEMISTRY; SOLUTION BEHAVIOR; LUNG-CANCER; SOLID-STATE; CRYSTAL;
D O I
10.1002/aoc.6540
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Organotin(IV) chemistry is nowadays in a continuous expansion due to the biological and medicinal potential found for some of these species. Within this study, the cytotoxic activity of several organotin(IV) compounds was investigated on two lung cancer cell lines (H522 and SK-MES-1) and on a normal lung cell line in order to have an overview of the toxicity and the selectivity of these derivatives. Moreover, the synthetic protocols, as well as the structural particularities of the novel organotin(IV) species, are also discussed. Hydrolysis of [2-{(CH2O)(2)CR}C6H4](2)SnPh2 [R = H (1), Me (2)] with p-toluenesulfonic acid as a proton source afford the expected derivatives [2-(OCR)C6H4](2)SnPh2 [R = H (3), Me (4)]. When hydrochloric acid is used in these reactions, a chlorine-phenyl exchange took place in addition to the removal of the acetal fragments and the following products [2-(OCR)C6H4](2)SnPhCl [R = H (5), Me (6)] were isolated. Treatment of 5 with 2 equiv of 3-aminomethylpyridine in neat affords the imino(aryl)tin compound 2-(3 '-PyCH2NCH)C6H4](2)SnPhCl (7). The reaction between 6 and potassium nicotinate allows the isolation of the organotin(IV) carboxylate [2-{OC (CH3)}C6H4](2)SnPh[O(O)CC5H4N-3] (8). Compounds 1-8 were characterized by multinuclear NMR spectroscopy in solution, mass spectrometry, and IR spectroscopy, and their molecular structures were confirmed by X-ray diffraction analysis. Compounds 1-8 were investigated for their antitumoral effects on Homo sapiens lung cancer cell lines (H522 and SK-MES-1) and on a normal bronchial epithelial cell line, BEAS-2B.
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页数:19
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