Location, location, location: The cancer stem cell niche

被引：137
|
作者：
Sneddon, Julie B. [1 ,2 ]
Werb, Zena [3 ]
机构：
[1] Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA
[2] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
[3] Univ Calif San Francisco, Dept Anat, Ctr Comprehens Canc, San Francisco, CA 94143 USA
来源：
CELL STEM CELL | 2007年 / 1卷 / 06期
关键词：
D O I：
10.1016/j.stem.2007.11.009
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The existence of a stem cell niche, or physiological microenvironment, consisting of specialized cells that directly and indirectly participate in stem cell regulation has been verified for mammalian adult stem cells in the intestinal, neural, epidermal, and hernatopoietic systems. In light of these findings, it has been proposed that a "cancer stem cell niche" also exists and that interactions with this tumor niche may specify a self-renewing population of tumor cells. We discuss emerging data that support the idea of a veritable cancer stem cell niche and propose several models for the relationship between cancer cells and their niches.
引用
收藏
页码：607 / 611
页数：5
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