Amantadine analogues - synthesis and biological activity

The biological activity of adamantane derivatives is due to the symmetry and steric bulkiness of the structure and the significant lipophilicity of the rigid hydrocarbon framework. This enables them to penetrate easily through biological membranes. Therefore, modification of organic compounds by an adamantyl radical changes significantly their biological activity, often enhancing it. A large number of strains that are completely resistant to amantadine are currently known. The number of resistant influenza strains increases every year because of spontaneous mutations in the virus genome. This necessitates expanded research on the reasons for the development of resistance and ways of overcoming it by creating new antiviral drugs [1].