Diffuse large B-cell lymphoma in the primary bone marrow

被引：7
|
作者：
Hu, Y. [1 ]
Chen, S. L. [1 ]
Huang, Z. X. [1 ]
Gao, W. [1 ]
An, N. [1 ]
机构：
[1] Capital Med Univ, Beijing Chaoyang Hosp, Dept Hematol, Beijing, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2015年 / 14卷 / 02期
关键词：
Bone marrow; Diffuse large B-cell lymphoma;
D O I：
10.4238/2015.June.9.10
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study aimed to improve understanding of the diagnosis, treatment, and prognosis of primary bone marrow (PBM) diffuse large B-cell lymphoma (DLBCL), a rare illness. We report a 56-year-old man with pancytopenia and hyperbilirubinemia but without lymphadenopathy, hepatomegaly, or splenomegaly. Bone marrow aspiration, flow cytometry, biopsy, and immunohistochemistry confirmed DLBCL. Two cycles of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone were administered. Blood cell numbers and hyperbilirubinemia improved. Although the patient did not completely recover, he survived for at least 3 years after chemotherapy and receiving blood transfusions. PBM DLBCL is a distinct, aggressive lymphoma characterized by lymphoma cells only in the bone marrow and effectively treated via chemotherapy. Prognoses for PBM DLBCL vary.
引用
收藏
页码：6247 / 6250
页数：4
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