Potent Toxic Macrocyclic Trichothecenes from the Marine-Derived Fungus Myrothecium verrucaria Hmp-F73

被引：2
|
作者：
Zhao, Li [1 ,2 ]
Liu, Li [1 ]
Wang, Nan [2 ]
Wang, Shu-Jin [1 ]
Hu, Jing-Chun [1 ]
Gao, Jin-Ming [2 ]
机构：
[1] Chinese Acad Sci, Inst Appl Ecol, Shenyang 110161, Peoples R China
[2] NW A&F Univ, Coll Sci, Res Ctr Nat Med Chem, Yangling 712100, Shaanxi, Peoples R China
来源：
NATURAL PRODUCT COMMUNICATIONS | 2011年 / 6卷 / 12期
基金：
国家高技术研究发展计划(863计划);
关键词：
Myrothecium verrucaria Hmp-F73; Hymeniacidon perleve; trichothecenes; mycotoxins; brine shrimp lethality; MYCOTOXINS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Activity-guided fractionation of a methanol extract from the culture broth of Myrothecium verrucaria Hmp-F73, a fungus associated with the sponge Hymeniacidon perleve, afforded six macrocyclic trichothecenes, verrucarin J (1), 8-hydroxyverrucarin J (2), verrucarin A (3), 8-acetoxyroridin (4), isororidin E (5), and roridin E (6), along with trichoverrin B (7). All seven metabolites displayed potent toxicity to the brine shrimp (Artemia sauna). In addition, compounds 2, 3, and 6 showed weak phytotoxic activities against lettuce seeds. A preliminary structure-activity relationship of the metabolites is also discussed.
引用
收藏
页码：1915 / 1916
页数：2
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