Potent Toxic Macrocyclic Trichothecenes from the Marine-Derived Fungus Myrothecium verrucaria Hmp-F73

被引：2

作者：

Zhao, Li ^{[1
,2
]}

Liu, Li ^{[1
]}

Wang, Nan ^{[2
]}

Wang, Shu-Jin ^{[1
]}

Hu, Jing-Chun ^{[1
]}

Gao, Jin-Ming ^{[2
]}

机构：

[1] Chinese Acad Sci, Inst Appl Ecol, Shenyang 110161, Peoples R China

[2] NW A&F Univ, Coll Sci, Res Ctr Nat Med Chem, Yangling 712100, Shaanxi, Peoples R China

来源：

NATURAL PRODUCT COMMUNICATIONS | 2011年 / 6卷 / 12期

基金：

国家高技术研究发展计划(863计划);

关键词：

Myrothecium verrucaria Hmp-F73; Hymeniacidon perleve; trichothecenes; mycotoxins; brine shrimp lethality; MYCOTOXINS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Activity-guided fractionation of a methanol extract from the culture broth of Myrothecium verrucaria Hmp-F73, a fungus associated with the sponge Hymeniacidon perleve, afforded six macrocyclic trichothecenes, verrucarin J (1), 8-hydroxyverrucarin J (2), verrucarin A (3), 8-acetoxyroridin (4), isororidin E (5), and roridin E (6), along with trichoverrin B (7). All seven metabolites displayed potent toxicity to the brine shrimp (Artemia sauna). In addition, compounds 2, 3, and 6 showed weak phytotoxic activities against lettuce seeds. A preliminary structure-activity relationship of the metabolites is also discussed.

引用

页码：1915 / 1916

页数：2

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