Effect of platelet-rich plasma intrauterine infusion on pregnancy outcomes in Egyptian infertile women

In reproductive medicine, recurrent implantation failure (RIF) is one of the nightmares and despite many approaches that have been suggested for management; there is no universal agreement yet. Beside its investigation as therapeutic approach for many medical disorders in rheumatology and dermatology, platelet-rich plasma (PRP) intrauterine infusion is suggested to promote endometrial receptivity, but its use in in vitro fertilization is still limited. This study aimed to investigate effectiveness of PRP intrauterine infusion before embryo transfer in women with RIF and to evaluate its effect on endometrial thickness, pregnancy rate and pregnancy outcomes. A total of 40 infertile women with RIF history were divided into 2 comparable groups. In the study group, PRP intrauterine infusion was performed 48 hours before blastocyst transfer. Using ultrasound, PRP intrauterine infusion significantly increased endometrial thickness (9.5 +/- 0.10 vs. 7.4 +/- 0.10 mm). Compared to women without PRP treatment (0%), PRP significantly (P=0.042) increased positive chemical and clinical pregnancy rates (25%). In PRP treated patients, only the increase in endometrial thickness (P=0.0001) was associated with pregnancy occurrence. In conclusion, this study shied the light on significant impact of intrauterine injection of PRP in pregnancy outcomes in patients with a history of RIF as it increases the endometrial thickness and pregnancy rates.