Efficacy of the Intrauterine Infusion of Platelet-Rich Plasma on Pregnancy Outcomes in Patients With Repeated Implantation Failure: A Randomized Control Trial

Objectives: The aim of the present study was to evaluate the effect of the intrauterine administration of platelet-rich plasma (PRP) before embryo transfer (ET) on pregnancy outcomes in women with repeated implantation failure (RIF). Materials and Methods: This randomized controlled trial included 120 RIF women who were candidates for frozen-thawed ET. In the PRP group (n = 60), the intrauterine infusion of 0.5 mL PRP was performed 48 hours before ET, and the control group (n=60) underwent ET without intrauterine administration. Results: The implantation rate (28% vs. 11.9%, P< 0.001), clinical pregnancy (51.6% vs. 26.6%, P= 0.005), and live birth rate (58.3% vs. 28.3%, P= 0.001) in PRP group were significantly higher compared to the control group. Based on the results, there was no significant difference with regard to miscarriage (12.5% vs. 12.9%, P = 0.97) and multiple pregnancy rate (0.133% vs. 0.05%, P= 0.11) between the two groups. Finally, preterm delivery was significantly higher in the PRP group (P< 0.001). Conclusions: According to this study, the result revealed that PRP is effective in the improvement of pregnancy outcomes in RIF patients. Further studies are needed to identify the group of patients who would benefit from this intervention.