Noncoding RNA Roles in Pharmacogenomic Responses to Aspirin: New Molecular Mechanisms for an Old Drug

被引：3

作者：

Khazeei Tabari, Mohammad Amin ^{[1
,2
]}

Mishan, Mohammad Amir ^{[3
]}

Moradi, Mona ^{[4
]}

Khandan, Mohanna ^{[1
,2
]}

Khoshhal, Hooman ^{[1
,2
]}

Mahrooz, Abdolkarim ^{[4
]}

Bagheri, Abouzar ^{[4
,5
]}

机构：

[1] Mazandaran Univ Med Sci, Student Res Comm, Sari, Iran

[2] Mazandaran Univ Med Sci, USERN Off, Sari, Iran

[3] Shahid Beheshti Univ Med Sci, Res Inst Ophthalmol & Vis Sci, Ocular Tissue Engn Res Ctr, Tehran, Iran

[4] Mazandaran Univ Med Sci, Fac Med, Mol & Cell Biol Res Ctr, Dept Clin Biochem & Med Genet, Sari, Iran

[5] Mazandaran Univ Med Sci, Fac Med, Gastrointestinal Canc Res Ctr, Dept Clin Biochem & Med Genet, Sari, Iran

来源：

BIOMED RESEARCH INTERNATIONAL | 2021年 / 2021卷

关键词：

TRIGGERED RESOLVIN D1; HEPATIC ISCHEMIA/REPERFUSION INJURY; CANCER PREVENTION; D-SERIES; MICRORNAS; INFLAMMATION; CELLS; MIR-21; ALPHA; RESISTANCE;

D O I：

10.1155/2021/6830560

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aspirin, as one of the most frequently prescribed drugs, can have therapeutic effects on different conditions such as cardiovascular and metabolic disorders and malignancies. The effects of this common cardiovascular drug are exerted through different molecular and cellular pathways. Altered noncoding RNA (ncRNA) expression profiles during aspirin treatments indicate a close relationship between these regulatory molecules and aspirin effects through regulating gene expressions. A better understanding of the molecular networks contributing to aspirin efficacy would help optimize efficient therapies for this very popular drug. This review is aimed at discussing and highlighting the identified interactions between aspirin and ncRNAs and their targeting pathways and better understanding pharmacogenetic responses to aspirin.

引用

页数：14

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