Effect of zinc supplementation on the immune status of healthy older individuals aged 55-70 years: The ZENITH study

被引：33
|
作者：
Hodkinson, Clare F. [1 ]
Kelly, Mary [1 ]
Alexander, H. Denis [1 ,2 ]
Bradbury, Ian [1 ]
Robson, Paula J. [1 ]
Bonham, Maxine P. [1 ]
O'Connor, Jacqueline M. [1 ]
Coudray, Charles [3 ]
Strain, J. J. [1 ]
Wallace, Julie M. W. [1 ]
机构：
[1] Univ Ulster, No Ireland Ctr Food & Hlth NICHE, Coleraine BT52 1SA, Londonderry, North Ireland
[2] Belfast City Hosp, Dept Haematol, Belfast, Antrim, North Ireland
[3] Ctr Rech Clermont Ferrand, Unite Maladies Matabol & Micronutriments INRA, Ctr Rech Nutr Humaine Auvergne, St Genes Champanelle, France
来源：
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2007年 / 62卷 / 06期
关键词：
D O I：
10.1093/gerona/62.6.598
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Aging is associated with alterations in the immune system, effects which may be exacerbated by inadequate zinc (Zn) status. We examined the relationship between Zn status and markers of immunity and the effect of supplementation with 15 mg or 30 mg Zn/d for 6 months on immune status in healthy individuals. Zn status was assessed by dietary intake and biochemical indices. Immune status was assessed by multiple flow cytometric methods. At baseline, Zn concentration was positively associated with lymphocyte subpopulation counts and T-lymphocyte activation. Zn supplementation of 30 mg/d significantly lowered B-lymphocyte count, albeit at month 3 only. Lower doses of Zn (15 mg Zn/d) significantly increased the ratio of CD4 to CD8 T lymphocytes at month 6. Overall, these findings suggest that total Zn intake (diet plus supplementation) of up to 40 mg Zn/d do not have significant long-term effects on immune status in apparently healthy persons aged 55-70 years.
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页码：598 / 608
页数：11
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