Total Synthesis and Absolute Stereochemistry of Seragakinone A

被引：49

作者：

Takada, Akiomi ^{[1
]}

Hashimoto, Yoshimitsu ^{[1
]}

Takikawa, Hiroshi ^{[1
]}

Hikita, Katsuyoshi ^{[1
]}

Suzuki, Keisuke ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Chem, Meguro Ku, Tokyo 1528551, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 10期

关键词：

antibiotics; cyclization; natural products; organocatalysis; total synthesis; AROMATIC NITRILE OXIDES; PROMOTED CYCLOCONDENSATION; ASYMMETRIC EPOXIDATION; HYPERVALENT IODINE; ISOXAZOLES; CONVERSION; CONSTRUCTION; OXIDATION; ALDEHYDES;

D O I：

10.1002/anie.201006528

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Cyclic transformation: The key transformations of the asymmetric total synthesis of the marine-derived natural product seragakinone A are two N-heterocyclic carbene catalyzed benzoin cyclizations that result in the construction of two rings and a pinacol-type rearrangement to install the angular prenyl substituent. © 2011 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2297 / 2301

页数：5

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