Susceptibility to multiple sclerosis: interplay between genes and environment

被引：49
|
作者：
Willer, CJ [1 ]
Ebers, GC [1 ]
机构：
[1] Univ Oxford, Radcliffe Infirm, Dept Clin Neurol, Oxford OX2 6HE, England
来源：
CURRENT OPINION IN NEUROLOGY | 2000年 / 13卷 / 03期
关键词：
D O I：
10.1097/00019052-200006000-00002
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Multiple sclerosis is a complex trait of unknown etiology. Epidemiological data have shown that susceptibility to multiple sclerosis is determined by both genetic and environmental factors. It is unknown whether the clinical subcategories of multiple sclerosis are separate diseases with separate etiologies and causes. Recent theories of the pathogenesis of multiple sclerosis and candidate genes are discussed. Other potential nonchromosomal factors involved in multiple sclerosis susceptibility such as mitochondrial DNA and viral factors such as Chlamydia pneumoniae are reviewed. Curr Opin Neurol 13:241-247. (C) 2000 Lippincott Williams & Wilkins.
引用
收藏
页码：241 / 247
页数：7
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