Expression of TCL-1 as a potential prognostic factor for treatment outcome in B-cell chronic lymphocytic leukemia

被引：13
|
作者：
Browning, Rebekah L. [1 ]
Geyer, Susan M. [2 ]
Johnson, Amy J. [1 ]
Jelinek, Diane E. [2 ]
Tschumper, Renee C. [2 ]
Call, Timothy G. [2 ]
Shanafelt, Tait D. [2 ]
Zent, Clive S. [2 ]
Bone, Nancy D. [2 ]
Dewald, Gordon W. [2 ]
Lin, Thomas S. [1 ]
Heerema, Nyla A. [1 ]
Grever, Michael R. [1 ]
Kay, Neil E. [2 ]
Byrd, John C. [1 ]
Lucas, David M. [1 ]
机构：
[1] Ohio State Univ, Columbus, OH 43210 USA
[2] Mayo Clin, Rochester, MN USA
来源：
LEUKEMIA RESEARCH | 2007年 / 31卷 / 12期
关键词：
chronic lymphocytic leukemia (CLL); TCL-1; prognostic factor; Pentostatin; chemoimmunotherapy;
D O I：
10.1016/j.leukres.2007.05.020
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
TCL-1 expression is variable in CLL, and no study has examined its association with treatment response. We measured TCL-1 protein in CLL cells from 51 patients who then received pentostatin, cyclophosphamide, and rituximab. TCL-1 expression did not correlate with any pre-treatment characteristics. Lower TCL-1 levels were associated with higher probability of attaining flow cytometry-negative status post-treatment (52% versus 17%, p = 0.046). Trends toward improved complete remission rate (49% versus 19%, p = 0.064) and progression-free survival (medians: 33 versus 20 months, p = 0.199) were noted with lower TCL-1 expression. These data suggest TCL-1 expression may help predict treatment outcome in CLL patients following chemoimmunotherapy, and examination in larger studies is warranted. Published by Elsevier Ltd.
引用
收藏
页码：1737 / 1740
页数：4
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