Experimental oral infection of bluetongue virus serotype 8 in type I interferon receptor-deficient mice

被引：23

作者：

Calvo-Pinilla, Eva ^{[1
]}

Maria Nieto, Jose ^{[1
]}

Ortego, Javier ^{[1
]}

机构：

[1] INIA, Ctr Invest Sanidad Anim, Madrid 28130, Spain

来源：

JOURNAL OF GENERAL VIROLOGY | 2010年 / 91卷

关键词：

CATTLE; CALVES; SHEEP; TRANSMISSION; PATHOGENESIS;

D O I：

10.1099/vir.0.024117-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The identification of transmission routes for bluetongue virus (BTV) is essential to improve the control of the disease. Although BTV is primarily transmitted by several species of Culicoides biting midges, there has been evidence of transplacental and oral transmission. We now report that IFNAR((-/-)) mice are susceptible to oral infection by BTV-8. Viraemia, clinical manifestations and tissue lesions are similar to those in intravenously infected mice. In addition, we show that the oral cavity and oesophagus are susceptible to BTV infection and replication, suggesting that these organs are possible entry routes during BTV oral infection.

引用

页码：2821 / 2825

页数：5

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