Pheochromocytoma in internal medicine: distinctive features and place of 123I MIBG scintigraphy

被引:9
|
作者
Noblet-Dick, M
Grunenberger, F
Brunot, B
Jaeck, D
Schlienger, JL
机构
[1] CHU Robertsau, Ctr Gerontol, F-67091 Strasbourg, France
[2] CHU Hautepierre, Serv Med Interne & Nutr, F-67098 Strasbourg, France
[3] CHU Hautepierre, Nucl Med Serv, F-67098 Strasbourg, France
[4] CHU Hautepierre, Serv Chirurg Gen Hepat & Endocrinienne, F-67098 Strasbourg, France
来源
REVUE DE MEDECINE INTERNE | 2003年 / 24卷 / 06期
关键词
pheochromocytoma; MIBG scintigraphy; urine metanephrines; urine normetanephrines;
D O I
10.1016/S0248-8663(03)00074-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose.-Pheochromocytoma diagnosis uses the localization of the tumour, particularly thanks to MIBG scintigraphy. The aims of this study were to evaluate the sensibility and specificity of this exam, his opportunity towards clinical and biological profile of patients with pheochromocytoma suspicion in Internal Medicine and towards others techniques of imaging. We tried to define the most effective and least expensive approach of pheochromocytoma diagnosis. Method.-This study was carried out over 15 years period on 80 patients in Internal Medicine who underwent 1231 MIBG scintigraphy for pheochromocytoma suspicion. Results.-Among the 80 patients who underwent 1231 MIBG scintigraphy, only 18 suffered from a pheochromocytoma. A very few symptoms were specific, like the triad "headaches, sweating, palpitations" whose onlyone third of patients was concerned by. The diagnosis approach carried on with urine catecholamine measurement, who was specific when metanephrines were increased whatever their levels and when normetanephrines were higher or equal than 1,5 time the norme. Then, abdominal CT or MRI scanning and 1231 MIBG scintigraphy were performed for localization of the tumor. The sensibility of scintigraphy was 83%, its specificity was 89%. That is comparable with other studies about 131I MIBG. Conclusion.-Prescription of MIBG scintigraphy in Internal Medicine appears to be excessive: 77,5% of patients don't have a pheochromocytoma. It is related to the lack of specific symptoms, the wrong positives in urine normetanephrines measurement and the discovery of incidentaloms by CT scanning. The scintigraphy should be used like a topographic and not a diagnosis exam. (C) 2003 Editions scientifiques et medicales Elsevier SAS. Tons droits reserves.
引用
收藏
页码:358 / 365
页数:8
相关论文
共 50 条
  • [21] CARDIAC 123I-MIBG SCINTIGRAPHY
    Wyborn, R.
    INTERNAL MEDICINE JOURNAL, 2011, 41 : 1 - 1
  • [22] Incidental uptake of 123I MIBG in brown fat
    Ochoa-Figueroa, M. A.
    Munoz-Iglesias, J.
    Allende-Riera, A.
    Cabello-Garcia, D.
    Martinez-Gimeno, E.
    DeSequera-Rahola, M.
    REVISTA ESPANOLA DE MEDICINA NUCLEAR E IMAGEN MOLECULAR, 2012, 31 (05): : 290 - 291
  • [23] Polymer-supported radiopharmaceuticals:: [131I]MIBG and [123I]MIBG
    Hunter, DH
    Zhu, XZ
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1999, 42 (07): : 653 - 661
  • [24] Polymer-supported radiopharmaceuticals: [131I]MIBG and [123I]MIBG
    Hunter, Duncan H.
    Zhu, Xizhen
    Journal of Labelled Compounds and Radiopharmaceuticals, 1999, 42 (07): : 653 - 661
  • [25] Evaluation of 123I-MIBG uptake into the adrenal medulla in 123I-MIBG scintigraphy
    Abe, S.
    Kato, K.
    Odagawa, T.
    Fujita, N.
    Fujita, Y.
    Niwa, A.
    Naganawa, S.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2013, 40 : S380 - S381
  • [26] 123I-MIBG scintigraphy of catecholamine systems:: impediments to applications in clinical medicine
    Eisenhofer, G
    Pacak, K
    Goldstein, DS
    Chen, C
    Shulkin, B
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 2000, 27 (05): : 611 - 612
  • [28] Pheochromocytoma in Multiple Endocrine Neoplasia Type 2A Positive 123I MIBG With Negative CT and Equivocal 131I MIBG Imaging
    Ishii, Shirou
    Shishido, Fumio
    Miyajima, Masayuki
    Sakuma, Kotaro
    Kikuchi, Ken
    CLINICAL NUCLEAR MEDICINE, 2012, 37 (06) : 596 - 598
  • [29] Positive I-123-MIBG-scintigraphy in osteosarcoma
    von der Hardt, K
    Bair, HJ
    Kirchner, T
    Feistel, H
    Beck, J
    NUKLEARMEDIZIN, 1998, 37 (02) : 73 - 75
  • [30] The value of I-123 MIBG scintigraphy in paraganglioma
    Milardovic, R.
    Stokkel, M. P. M.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2009, 36 : S266 - S266