Activin A Secreted From Peripheral Nerve Fibroblasts Promotes Proliferation and Migration of Schwann Cells

被引:16
|
作者
Li, Yan [1 ,2 ]
Cheng, Zhenghang [2 ]
Yu, Fanhui [2 ]
Zhang, Qi [2 ]
Yu, Shu [2 ]
Ding, Fei [2 ]
He, Qianru [2 ]
机构
[1] Soochow Univ, Sch Biol & Basic Med Sci, Suzhou, Peoples R China
[2] Nantong Univ, Coinnovat Ctr Neuroregenerat, Key Lab Neuroregenerat Jiangsu, Minist Educ, Nantong, Peoples R China
来源
关键词
activin A; fibroblasts; Schwann cells; proliferation; migration; cytokine array; peripheral nervous system; NEURITE OUTGROWTH;
D O I
10.3389/fnmol.2022.859349
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The peripheral nervous system has remarkable regenerative capabilities. Schwann cells and fibroblasts are known to play crucial roles in these processes. In this study, we delineated the differential effects of peripheral nerve fibroblasts and cardiac fibroblasts on Schwann cells. We found that peripheral nerve fibroblasts significantly promoted Schwann cell proliferation and migration compared with cardiac fibroblasts. The cytokine array results identified 32 of 67 proteins that were considered differentially expressed in peripheral nerve fibroblasts versus cardiac fibroblasts. Among them, 25 were significantly upregulated in peripheral nerve fibroblasts compared with cardiac fibroblasts. Activin A, the protein with the greatest differential expression, clearly co-localized with fibroblasts in the in vivo sciatic never injury rat model. In vitro experiments proved that activin A secreted from nerve fibroblasts is the key factor responsible for boosting proliferation and migration of Schwann cells through ALK4, ALK5, and ALK7. Overall, these findings suggest that peripheral nerve fibroblasts and cardiac fibroblasts exhibit different patterns of cytokine secretion and activin A secreted from peripheral nerve fibroblasts can promote the proliferation and migration of Schwann cells.
引用
收藏
页数:14
相关论文
共 50 条
  • [41] Erythropoietin promotes M2 macrophage phagocytosis of Schwann cells in peripheral nerve injury
    Prem Kumar Govindappa
    John C. Elfar
    Cell Death & Disease, 13
  • [42] Erythropoietin promotes M2 macrophage phagocytosis of Schwann cells in peripheral nerve injury
    Govindappa, Prem Kumar
    Elfar, John C.
    CELL DEATH & DISEASE, 2022, 13 (03)
  • [43] Long noncoding RNA Pvt1 promotes the proliferation and migration of Schwann cells by sponging microRNA-214 and targeting c-Jun following peripheral nerve injury
    Pan, Bin
    Guo, Di
    Jing, Li
    Li, Ke
    Li, Xin
    Li, Gen
    Gao, Xiao
    Li, Zhi-Wen
    Zhao, Wei
    Feng, Hu
    Cao, Meng-Han
    NEURAL REGENERATION RESEARCH, 2023, 18 (05) : 1147 - 1153
  • [44] Long noncoding RNA Pvt1 promotes the proliferation and migration of Schwann cells by sponging microRNA-214 and targeting c-Jun following peripheral nerve injury
    Bin Pan
    Di Guo
    Li Jing
    Ke Li
    Xin Li
    Gen Li
    Xiao Gao
    Zhi-Wen Li
    Wei Zhao
    Hu Feng
    Meng-Han Cao
    Neural Regeneration Research, 2023, 18 (05) : 1147 - 1153
  • [45] Survival and migration of Schwann cells after the vascularized peripheral nerve grafted into spinal cord in rats
    郭庆山
    王爱民
    王晓军
    孙红振
    杜全印
    Journal of Medical Colleges of PLA, 2005, (04) : 232 - 235
  • [46] LncRNA BC088259 promotes Schwann cell migration through Vimentin following peripheral nerve injury
    Yao, Chun
    Chen, Yanping
    Wang, Jing
    Qian, Tianmei
    Feng, Wei
    Chen, Yuanyuan
    Mao, Susu
    Yu, Bin
    GLIA, 2020, 68 (03) : 670 - 679
  • [47] NUAK2 mediated regulation of Schwann Cell proliferation and migration in peripheral nerve injury via YAP
    Zhang, Weidong
    Ni, Yingchen
    Li, Jianxin
    Hua, Runjia
    Wang, Yudong
    Yang, Huilin
    Li, Xuefeng
    Gan, Minfeng
    Chu, Genglei
    HELIYON, 2024, 10 (13)
  • [48] Tau Isoform-Regulated Schwann Cell Proliferation and Migration Improve Peripheral Nerve Regeneration After Injury
    Li, Shiying
    Zhang, Fuqian
    Wang, Guifang
    Liu, Qianyan
    Wang, Xinghui
    Chen, Qianqian
    Chu, Dandan
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (22)
  • [49] Increased levels of miR-3099 induced by peripheral nerve injury promote Schwann cell proliferation and migration
    Liu, Qian-Yan
    Miao, Yang
    Wang, Xing-Hui
    Wang, Pan
    Cheng, Zhang-Chun
    Qian, Tian-Mei
    NEURAL REGENERATION RESEARCH, 2019, 14 (03) : 525 - 531
  • [50] Increased levels of miR-3099 induced by peripheral nerve injury promote Schwann cell proliferation and migration
    Qian-Yan Liu
    Yang Miao
    Xing-Hui Wang
    Pan Wang
    Zhang-Chun Cheng
    Tian-Mei Qian
    Neural Regeneration Research, 2019, 14 (03) : 525 - 531