A large-scale synthesis of enantiomerically pure cetirizine dihydrochloride using preparative chiral HPLC

被引：24

作者：

Pflum, DA ^{[1
]}

Wilkinson, HS ^{[1
]}

Tanoury, GJ ^{[1
]}

Kessler, DW ^{[1
]}

Kraus, HB ^{[1
]}

Senanayake, CH ^{[1
]}

Wald, SA ^{[1
]}

机构：

[1] Sepracor Inc, Chem Res & Dev, Marlborough, MA 01752 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2001年 / 5卷 / 02期

关键词：

D O I：

10.1021/op0002951

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Enantiomerically pure cetirizine can be prepared by preparative HPLC separation of cetirizine amide, The amide has an alpha value of 2.76 (USP resolution of 8.54) using a Chiralpak AD column, and 0.5 wt % of the amide (based on packing material) can be injected per run.

引用

页码：110 / 115

页数：6

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