N-Methyl-D-aspartate receptors in the ventral tegmental area are involved in retrieval of inhibitory avoidance memory by nicotine

被引:24
|
作者
Ahmadi, Shamseddin
Zarrindast, Mohammad Reza
Nouri, Maryam
Haeri-Rohani, All
Rezayof, Ameneh
机构
[1] Univ Tehran Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran
[2] Univ Tehran Med Sci, Sch Med, Iraniant Natl Ctr Addict Studies, Tehran, Iran
[3] Univ Tehran, Univ Coll Sci, Sch Biol, Dept Anim Biol, Tehran, Iran
[4] Sch Cognit Sci, Inst Studies Theoret Phys & Math, Tehran, Iran
[5] Inst Cognit Sci Studies, Tehran, Iran
关键词
morphine; nicotine; NMDA; VTA; retrieval; state-dependency; rat;
D O I
10.1016/j.nlm.2007.07.001
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The interaction of opiate, cholinergic, glutamatergic and (possibly) dopaminergic inputs in the ventral tegmental area (VTA) influencing a learned behavior is certainly a topic of great interest. In the present study, the effect of intra-VTA administration of N-methyl-D-aspartate (NMDA) receptor agents on nicotine's effect in morphine state-dependent learning was investigated. An inhibitory avoidance (IA) task was used for memory assessment in male Wistar rats. Subcutaneous (s.c.) administration of morphine (5 and 7.5 mg/ kg) immediately after training decreased IA response on the test day, which was reinstated by pre-test administration of the same doses of the opioid.- this is known as state-dependency. Moreover, pre-test administration of nicotine (0.2, 0.4 and 0.6 mg/kg, s.c.) also reversed the decrease in IA response because of post-training morphine (5 mg/kg). Here, we also show that when infused into the VTA before testing, NMDA (0.01 and 0. 1 mu g/rat) reverse the post-training morphine effect on memory. In addition, the sub-effective doses of NMDA (0.0001 and 0.001 mu g/rat) in combination with a low dose of nicotine (0.1 mg/kg) which had no effects by themselves, synergistically improved retrieval of IA memory on the test day. In contrast, pre-test administration of a competitive NMDA receptor antagonist D-AP5 (0.5 1 and 2 mu g/rat) which had no effect alone prevented the nicotine reversal of morphine effect on memory. Our data indicate that NMDA receptors in the VTA are involved in the reversing effect of nicotine on morphine induced state-dependency. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:352 / 358
页数:7
相关论文
共 50 条
  • [41] EFFECTS OF CHRONIC TREATMENT WITH (+)-NICOTINE AND (-)-NICOTINE ON NICOTINIC ACETYLCHOLINE-RECEPTORS AND N-METHYL-D-ASPARTATE RECEPTORS IN RAT-BRAIN
    ZHANG, X
    GONG, ZH
    NORDBERG, A
    BRAIN RESEARCH, 1994, 644 (01) : 32 - 39
  • [42] N-METHYL-D-ASPARTATE RECEPTORS ARE TRANSIENTLY EXPRESSED IN THE DEVELOPING SPINAL-CORD VENTRAL HORN
    KALB, RG
    LIDOW, MS
    HALSTED, MJ
    HOCKFIELD, S
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (18) : 8502 - 8506
  • [43] N-methyl-D-aspartate receptors in opioid dependence and withdrawal
    Rockhold, R
    Zhu, H
    Liu, NS
    Ho, IK
    CATECHOLAMINE RESEARCH: FROM MOLECULAR INSIGHTS TO CLINICAL MEDICINE, 2002, 53 : 389 - 392
  • [44] DESENSITIZATION OF N-METHYL-D-ASPARTATE RECEPTORS - A PROBLEM OF INTERPRETATION
    COLQUHOUN, D
    HAWKES, AG
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (22) : 10327 - 10329
  • [45] Opiate physical dependence and N-methyl-D-aspartate receptors
    Noda, Y
    Nabeshima, T
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2004, 500 (1-3) : 121 - 128
  • [46] N-methyl-D-aspartate receptors in hyperammonaemia and hepatic encephalopathy
    Erceg, S.
    Rodrigo, R.
    Monfort, P.
    Llansalo, M.
    Montoliu, C.
    Sanchez-Perez, A. M.
    Cauli, O.
    Piedrafita, B.
    Felipo, V.
    HEPATIC ENCEPHALOPATHY AND NITROGEN METABOLISM, 2006, : 183 - 193
  • [47] THE RELATIONSHIP OF N-METHYL-D-ASPARTATE RECEPTORS AND MAJOR DEPRESSION
    Zhang, H. S.
    Shi, L. J.
    Sun, L. X.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2016, 119 : 29 - 29
  • [48] Antagonism of stimulation-produced analgesia by naloxone and N-methyl-D-aspartate: role of opioid and N-methyl-D-aspartate receptors
    Mehta, A. K.
    Halder, S.
    Khanna, N.
    Tandon, O. P.
    Sharma, K. K.
    HUMAN & EXPERIMENTAL TOXICOLOGY, 2012, 31 (01) : 51 - 56
  • [49] Localization and functions of neurokinin and N-methyl-D-aspartate receptors
    Adam, B
    Liebregts, T
    Gerken, G
    Holtmann, G
    GASTROINTESTINAL INFLAMMATION AND DISTURBED GUT FUNCTION: THE CHALLENGE OF NEW CONCEPTS, 2003, 130 : 253 - 259
  • [50] N-METHYL-D-ASPARTATE RECEPTORS AND NITRIC-OXIDE
    BOCKAERT, J
    OLIVIER, M
    MANZONI, O
    LAFONCAZAL, M
    MARIN, P
    FAGNI, L
    JOURNAL OF NEUROCHEMISTRY, 1993, 61 : S52 - S52