Involvement of an angiotensin II type 2 receptor (AT2R) signalling in human pancreatic ductal adenocarcinoma (PDAC): a novel AT2R agonist effectively attenuates growth of PDAC grafts in mice

被引:0
|
作者
Ishiguro, Susumu [1 ]
Yoshimura, Kiyoshi [2 ]
Takao, Sonshin [3 ]
Kawabata, Atsushi [1 ]
Wall, Terrahn [1 ]
Tsunedomi, Ryouichi [2 ]
Oka, Masaaki [2 ]
Inui, Makoto [4 ]
Pappas, Charalambos [5 ]
Tzakos, Andreas G. [5 ]
Tamura, Masaaki [1 ]
机构
[1] Kansas State Univ, Dept Anat & Physiol, Manhattan, KS 66506 USA
[2] Yamaguchi Univ, Dept Surg Oncol, Yamaguchi, Japan
[3] Kagoshima Univ, Ctr Biomed Sci & Swine Res, Kagoshima 890, Japan
[4] Yamaguchi Univ, Dept Pharmacol, Yamaguchi, Japan
[5] Univ Ioannina, Dept Chem, Ioannina, Greece
关键词
D O I
10.1158/1538-7445.AM2014-4606
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4606
引用
收藏
页数:2
相关论文
共 50 条
  • [42] Central Amygdala Angiotensin Type 2 Receptor (AT2R) Activation Reduces Fear-Related Behavior
    Yu, Zhe
    Swiercz, Adam
    Krause, Eric
    Marvar, Paul
    BIOLOGICAL PSYCHIATRY, 2019, 85 (10) : S309 - S310
  • [43] Non-clinical characterization of the disposition of EMA401, a novel small molecule angiotensin II type 2 receptor (AT2R) antagonist
    Murgasova, Renata
    Carreras, Ester Tor
    Suetterlin-Hachmann, Martina
    Torrao, Leonel Reis da Silva
    Kittelmann, Matthias
    Alexandra, Vargas
    Fredenhagen, Andreas
    BIOPHARMACEUTICS & DRUG DISPOSITION, 2020, 41 (4-5) : 166 - 183
  • [44] Exaggerated left ventricular dysfunction and increased early mortality after myocardial infarction in mice lacking type 2 angiotensin II receptor (AT2R) gene
    Oishi, Y
    Ozono, R
    Yano, Y
    Oshima, T
    Kambe, M
    Akishita, M
    Horiuchi, M
    HYPERTENSION, 2002, 40 (03) : 389 - 389
  • [46] AT2R's (Angiotensin II Type 2 Receptor's) Role in Cognitive and Cerebrovascular Deficits in a Mouse Model of Alzheimer Disease
    Royea, Jessika
    Lacalle-Aurioles, Maria
    Trigiani, Lianne J.
    Fermigier, Alice
    Hamel, Edith
    HYPERTENSION, 2020, 75 (06) : 1464 - 1474
  • [47] Effects of angiotensin II receptor type 2 (AT2R) modulation on fear memory in a mouse model of Posttraumatic Stress Disorder (PTSD)
    Swiercz, Adam P.
    Wiaderkiewicz, Jan P.
    Moshfegh, Cassandra
    Hopkins, Lauren
    Marvar, Paul J.
    FASEB JOURNAL, 2016, 30
  • [48] Suppression of Organismal Death Pathway in the Heart Tissues of Diabetic Mice by NP-6A4, A Peptide Agonist of the Angiotensin II Receptor AT2R
    Pulakat, Lakshmi
    Belenchia, Anthony
    Mooney, Brian
    DeMarco, Vincent
    FASEB JOURNAL, 2020, 34
  • [49] Emerging Role of Angiotensin Type 2 Receptor (AT2R)/Akt/NO Pathway in Vascular Smooth Muscle Cell in the Hyperthyroidism
    Carrillo-Sepulveda, Maria Alicia
    Ceravolo, Graziela S.
    Furstenau, Cristina R.
    Monteiro, Priscilla de Souza
    Bruno-Fortes, Zuleica
    Carvalho, Maria Helena
    Laurindo, Francisco R.
    Tostes, Rita C.
    Webb, R. Clinton
    Barreto-Chaves, Maria Luiza M.
    PLOS ONE, 2013, 8 (04):
  • [50] Angiotensin II type 2 receptor (AT2R) downregulates AT1R through bradykininin/NO system in VSMC from WKY but not in VSMC from SHR
    Fukuda, N
    Su, J
    Jin, X
    Lai, Y
    Suzuki, R
    Tahira, Y
    Ikeda, Y
    Kanmatsuse, K
    Miyzaki, H
    JOURNAL OF HYPERTENSION, 2002, 20 : S66 - S66