Laccase-poly(lactic-co-glycolic acid) (PLGA) nanofiber: Highly stable, reusable, and efficacious for the transformation of diclofenac

被引：68
|
作者：
Sathishkumar, Palanivel [1 ]
Chae, Jong-Chan [1 ]
Unnithan, Afeesh R. [2 ]
Palvannan, Thayumanavan [3 ]
Kim, Hak Yong [2 ]
Lee, Kui-Jae [1 ]
Cho, Min [1 ]
Kamala-Kannan, Seralathan [1 ]
Oh, Byung-Taek [1 ]
机构：
[1] Chonbuk Natl Univ, Coll Environm & Bioresource Sci, Adv Inst Environm & Biosci, Div Biotechnol, Iksan 570752, Jeonbuk, South Korea
[2] Chonbuk Natl Univ, Ctr Healthcare Technol & Dev, Jeonju 561756, Jeonbuk, South Korea
[3] Periyar Univ, Dept Biochem, Lab Bioproc & Engn, Salem 636011, Tamil Nadu, India
来源：
ENZYME AND MICROBIAL TECHNOLOGY | 2012年 / 51卷 / 02期
关键词：
Diclofenac; Laccase; Nanofiber; Stability; Transformation; TRAMETES-VERSICOLOR LACCASE; POLYMER NANOFIBERS; IMMOBILIZATION; DEGRADATION; MEMBRANES; TOXICITY; CATALASE; REMOVAL;
D O I：
10.1016/j.enzmictec.2012.05.001
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Nanobiocatalysis has received growing attention for use in commercial applications. We investigated the efficiency, stability, and reusability of laccase-poly(lactic-co-glycolic acid) (PLGA) nanofiber for diclofenac transformation. N-H stretching vibrations (3400-3500 cm(-1) and 1560 cm(-1)) in FT-IR spectra confirmed immobilization of laccase on PLGA nanofibers. The relative activity of immobilized laccase was 82% that of free laccase. Immobilized laccase had better storage, pH, and thermal stability than free laccase. The immobilized laccase produced complete diclofenac transformation in three reuse cycles, which was extended to 6 cycles in the presence of syringaldehyde. Results suggest that laccase-PLGA nanofiber may be useful for removing diclofenac from aqueous sources and has potential for other commercial applications. (c) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：113 / 118
页数：6
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