Assessing CMPI potentiation of (α4)3(β2)2 nicotinic acetylcholine receptor using the Monod-Wyman-Changeux allosteric model

被引：0
|
作者：
Deba, Farah [1 ]
Akk, Gustav [2 ]
Hamouda, Ayman [1 ]
机构：
[1] Univ Texas Tyler, Tyler, TX 75799 USA
[2] Washington Univ, St Louis, MO 14263 USA
来源：
FASEB JOURNAL | 2020年 / 34卷
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1096/fasebj.2020.34.s1.03706
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页数：2
相关论文
共 50 条
  • [21] Allosteric modulators of the α4β2 subtype of neuronal nicotinic acetylcholine receptors
    Pandya, Anshul
    Yakel, Jerrel L.
    BIOCHEMICAL PHARMACOLOGY, 2011, 82 (08) : 952 - 958
  • [22] Identification of a Negative Allosteric Site on Human α4β2 and α3β4 Neuronal Nicotinic Acetylcholine Receptors
    Pavlovicz, Ryan E.
    Henderson, Brandon J.
    Bonnell, Andrew B.
    Boyd, R. Thomas
    McKay, Dennis B.
    Li, Chenglong
    PLOS ONE, 2011, 6 (09):
  • [23] Agonist-Specific Pharmacological Effects of CMPI and NS9283 at (α4) 3(β2)2 Neuronal Nicotinic. Acetylcholine Receptors
    Munoz, Kemburli
    Deba, Farah
    Hamouda, Ayman K.
    BIOPHYSICAL JOURNAL, 2018, 114 (03) : 296A - 296A
  • [24] 2NDEP highlights allosteric activation of the α7 nicotinic acetylcholine receptor
    Gulsevin, Alican
    Stokes, Clare
    Papke, Roger
    Quadri, Marta
    Horenstein, Nicole
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
  • [25] Computational characterization of the binding of allosteric potentiators to the α4-α4 interface of the α4β2 LS nicotinic acetylcholine receptor
    Viscarra, Franco
    Biggin, Philip C.
    Bermudez, Isabel
    BIOPHYSICAL JOURNAL, 2024, 123 (03) : 161A - 161A
  • [26] Examining the Effects of (α4)3(β2)2 Nicotinic Acetylcholine Receptor-Selective Positive Allosteric Modulator on Acute Thermal Nociception in Rats
    Deba, Farah
    Ramos, Kara
    Vannoy, Matthew
    Munoz, Kemburli
    Akinola, Lois S.
    Damaj, M. Imad
    Hamouda, Ayman K.
    MOLECULES, 2020, 25 (12):
  • [27] A Pharmacophore for Drugs Targeting the α4α4 Binding Site of the (α4)3(β2)2 Nicotinic Acetylcholine Receptor
    Kusay, Ali S.
    Luo, Yujia
    O'Mara, Megan L.
    Balle, Thomas
    JOURNAL OF NEUROCHEMISTRY, 2025, 169 (02)
  • [28] The (α4)3(β2)2 Stoichiometry of the Nicotinic Acetylcholine Receptor Predominates in the Rat Motor Cortex
    DeDominicis, Kristen E.
    Sahibzada, Niaz
    Olson, Thao T.
    Xiao, Yingxian
    Wolfe, Barry B.
    Kellar, Kenneth J.
    Yasuda, Robert P.
    MOLECULAR PHARMACOLOGY, 2017, 92 (03) : 327 - 337
  • [29] An allosteric modulator of α4β2 nicotinic acetylcholine receptor potentiates GABAergic inputs to cholinergic interneurons in the mouse striatum
    Miura, Masami
    Inoue, Ritsuko
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2016, 19 : 307 - 307
  • [30] The β2 subunit C loop of the nicotinic acetylcholine receptor directs allosteric modulator specificity
    Levandoski, M. M.
    Mack, A. R.
    Sibbald, C. A.
    BIOCHEMICAL PHARMACOLOGY, 2015, 97 (04) : 625 - 625
12345