Inactivation of Smad4/DPC4 is responsible for the loss of the tumor suppressant 4E-BP1 in pancreatic adenocarcinoma

被引：0
|
作者：
Azar, R. [1 ]
Susini, C. [1 ]
Pyronnet, S. [1 ]
Aftimos, G. [1 ]
Tawil, A. [1 ]
Geahchan, A. [1 ]
机构：
[1] CHU Rangueil, INSERM, U858, F-31432 Toulouse, France
来源：
BULLETIN DU CANCER | 2007年 / 94卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
P24
引用
收藏
页码：S285 / S286
页数：2
相关论文
共 50 条
  • [31] Haploinsufficiency of the tumor suppressor Smad4/Dpc4 initiates gastrointestinal polyposis and cancer.
    Brodie, SG
    Xu, XL
    Yang, X
    Im, YH
    Parks, WT
    Chen, L
    Zhou, YX
    Xie, JW
    Kim, SJ
    Deng, CX
    MOLECULAR BIOLOGY OF THE CELL, 1999, 10 : 431A - 431A
  • [32] Differential gene expression analysis in a DPC4/Smad4 model system
    Souquet, M
    Schwarte-Waldhoff, I
    Schmiegel, W
    Hahn, SA
    GASTROENTEROLOGY, 2002, 122 (04) : A123 - A123
  • [33] Analysis of SMAD4/DPC4 gene alterations in multiploid colorectal carcinomas
    Tatsuya Ando
    Tamotsu Sugai
    Wataru Habano
    Yu-Fei Jiao
    Kazuyuki Suzuki
    Journal of Gastroenterology, 2005, 40 : 708 - 715
  • [34] Modulation of pancreas cancer invasion and metastasis by SMAD4/DPC4 signaling
    Goel, Vikas K.
    Rani, P. G.
    Izeradjene, Kamel
    Calses, Philamer
    Gard, Catherine
    Provenzano, Paolo P.
    Chang, Amy E.
    Lin, Hsin-Pin
    Hingorani, Sunil R.
    CANCER RESEARCH, 2011, 71
  • [35] MicroRNA 483-3p suppresses the expression of DPC4/Smad4 in pancreatic cancer
    Hao, Jun
    Zhang, Shuyu
    Zhou, Yingqi
    Hu, Xiangui
    Shao, Chenghao
    FEBS LETTERS, 2011, 585 (01) : 207 - 213
  • [36] Analysis of 5′-flanking region of human Smad4 (DPC4) gene
    Minami, R
    Kitazawa, R
    Maeda, S
    Kitazawa, S
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1998, 1443 (1-2): : 182 - 185
  • [37] 4E-BP1 loss of function in pancreatic carcinogenesis
    Azar, Rania
    Susini, Christiane
    Bousquet, Corinne
    Pyronnet, Stephane
    CANCER RESEARCH, 2010, 70
  • [38] Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers
    Hilgers, W
    Song, JJ
    Haye, M
    Hruban, RR
    Kern, SE
    Fearon, ER
    GENES CHROMOSOMES & CANCER, 2000, 27 (04): : 353 - 357
  • [39] Elucidation of the Role of SMAD4 in Epithelial-Mesenchymal Plasticity: Does It Help to Better Understand the Consequences of DPC4 Inactivation in the Malignant Progression of Pancreatic Ductal Adenocarcinoma?
    Ungefroren, Hendrik
    Konukiewitz, Bjoern
    Braun, Ruediger
    Wellner, Ulrich Friedrich
    Keck, Tobias
    Marquardt, Jens-Uwe
    CANCERS, 2023, 15 (03)
  • [40] DPC4/SMAD4 gene alterations in human cancer, and their functional implications
    Schutte, M
    ANNALS OF ONCOLOGY, 1999, 10 : 56 - 59
12345