Plasma MicroRNA Expression Profiles in Psoriasis

被引:25
|
作者
Xiao, Shiju [1 ,2 ]
Liu, Xin [1 ,3 ]
Wang, Xiaoxu [1 ,2 ]
Lv, Hongpeng [4 ]
Zhao, Junbo [5 ]
Guo, Xinwei [1 ,2 ,3 ]
Xian, Fuyang [4 ]
Ji, Yunrun [1 ]
Zhang, Guangzhong [1 ]
机构
[1] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Beijing 100010, Peoples R China
[2] Capital Med Univ, Grad Sch, Beijing 100069, Peoples R China
[3] Beijing Inst Tradit Chinese Med, Beijing 100010, Peoples R China
[4] Beijing Univ Chinese Med, Beijing 100029, Peoples R China
[5] Beijing Daxing Dist Hosp Integrated Tradit Chines, Beijing 100076, Peoples R China
关键词
SIGNALING PATHWAY; COGNITIVE DYSFUNCTION; CELL-PROLIFERATION; DISEASE-ACTIVITY; GENE-EXPRESSION; DOWN-REGULATION; POTENTIAL ROLE; APOPTOSIS; SKIN; INFLAMMATION;
D O I
10.1155/2020/1561278
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. Psoriasis is an immune-mediated inflammatory chronic skin disease characterized by chronic inflammation in the dermis, parakeratosis, and excessive epidermal growth. MicroRNAs (miRNAs) are key regulators of immune responses. Although differential expression of miRNAs has been reported in certain inflammatory autoimmune diseases, their role in psoriasis has not been fully illuminated. Our aims were to confirm plasma miRNA expression signatures in psoriasis and to examine their potential influence on psoriasis pathogenesis. Methods. A miRNome PCR array was used to analyse the plasma of psoriasis patients and healthy donors. We performed miRNA pathway enrichment and target gene network analyses on psoriasis plasma samples. Results. We found several specific plasma miRNA signatures relevant to psoriasis. The miRNAs targeted pathways associated with psoriasis, such as the VEGF, MAPK, and WNT signaling pathways. Network analysis revealed pivotal deregulated plasma miRNAs and their relevant target genes and pathways regulating psoriasis pathogenesis. Conclusions. This study analysed the expression of plasma miRNAs and their target pathways, elucidating the pathogenesis of psoriasis; these results may be used to design novel therapeutic strategies and to identify diagnostic biomarkers for psoriasis.
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页数:12
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