Necrotizing enterocolitis in a full-term infant.: Is acyclovir involved?

被引：1

作者：

Montjaux-Regis, N. ^{[1
]}

Chanot, A. ^{[1
]}

Olivier, P. ^{[2
]}

Damase-Michel, C. ^{[2
]}

Mengelle, C. ^{[3
]}

Glorieux, I. ^{[1
]}

Casper, C. ^{[1
,4
]}

机构：

[1] Hop Enfants, Neonatol Unit, F-31059 Toulouse 09, France

[2] Fac Med, Ctr Midi Pyrenees Pharmacovigilance, Pharmacol Med & Clin, F-31000 Toulouse, France

[3] Hop Purpan, Virol Unit, F-31000 Toulouse, France

[4] Hop Purpan, Unite Inserm U563, F-31000 Toulouse, France

来源：

ARCHIVES DE PEDIATRIE | 2007年 / 14卷 / 12期

关键词：

D O I：

10.1016/j.arcped.2007.08.013

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Acyclovir is a synthetic nucleoside analogue active against herpes viruses. Exposure during human pregnancy and during the neonatal period seems safe. We report a case of early necrotizing enterocolitis in a full term infant treated with acyclovir as a prophylactic therapy. The mother had herpes genitalis with preterm, premature ruture of membranes at 32 weeks of gestational age and was treated with acyclovir until vaginal delivery. Acyclovir treatment in utero and after birth is discussed as a possible cause of necrotizing enterocolitis in the infant. Acyclovir should be used only if its benefit outweighs the potential risk to the baby. (c) 2007 Publie par Elsevier Masson SAS.

引用

页码：1420 / 1423

页数：4

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