Phytochemical study and evaluation of the antimicrobial activity and cytotoxicity of Cuscuta racemosa

被引：8
|
作者：
Ferraz, Helena O. [1 ]
Silva, Magali G. [1 ]
Carvalho, Rui [2 ]
Suffredini, Ivana B. [3 ]
Kato, Edna T. M. [4 ]
Arakaki, Fernanda [4 ]
Bacchi, Elfriede M. [4 ]
机构：
[1] Univ Sorocaba, BR-18023000 Sorocaba, SP, Brazil
[2] Univ Coimbra, Dept Bioquim, Fac Ciencias & Tecnol, P-3000 Coimbra, Portugal
[3] Univ Paulista, Lab Extracao, Sao Paulo, Brazil
[4] Univ Sao Paulo, Dept Farm, Fac Ciencias Farmaceut, BR-05508 Sao Paulo, Brazil
来源：
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2011年 / 21卷 / 01期
关键词：
Cuscuta racemosa; Convolvulaceae; antimicrobial activity; cytotoxicity; PHENOLIC CONSTITUENTS; ERGOLINE ALKALOIDS; PARASITIC PLANTS; CONVOLVULACEAE; CHINENSIS;
D O I：
10.1590/S0102-695X2011005000005
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Cuscuta racemosa Mart. is a parasitic plant of the Convolvulaceae family, used in popular medicine as an anti-inflammatory and a diuretic, for stomach and hepatic disorders, and for treating fresh wounds. This plant is popularly known as "cipo-chumbo" and "fios-de-ovos". In this study, it was chemically investigated and tested for its antimicrobial activity and cytotoxicity. The flavonoid and tannin content of the dried plant were 2.79% and 2.01%, respectively. Furthermore, the 4'-methoxyquercetin flavanoid compound was isolated from the ethanolic fraction. The minimum inhibiting concentration in the antimicrobial test was 2.0 mg/mL for Staphylococcus aureus, and a DL50 of 0.231 mg/mL was obtained in the cytotoxicity experiment. The fraction directed to alkaloids was able to eliminate 100% of the brine shrimp used for the test.
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页码：41 / 46
页数：6
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