Straightforward synthesis of enantiopure (R)- and (S)-trifluoroalaninol

被引：10

作者：

Pytkowicz, Julien ^{[1
]}

Stephany, Olivier ^{[1
]}

Marinkovic, Sinisa ^{[1
]}

Inagaki, Sebastien ^{[1
]}

Brigaud, Thierry ^{[1
]}

机构：

[1] Univ Cergy Pontoise, Lab SOSCO, F-95000 Cergy Pontoise, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 20期

关键词：

BETA-AMINO ALCOHOLS; ASYMMETRIC-SYNTHESIS; ALPHA-AMINO; STEREOSELECTIVE-SYNTHESIS; ETHYL TRIFLUOROPYRUVATE; CHIRAL AUXILIARIES; 1,2-AMINO ALCOHOLS; EFFICIENT APPROACH; CONTAINING LIGANDS; BUILDING-BLOCKS;

D O I：

10.1039/c0ob00424c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two efficient routes are reported for the synthesis of both enantiomers of trifluoroalaninol in enantiopure form. The first pathway involves a Strecker-type reaction performed from a chiral trifluoromethyloxazolidine (Fox). The second route, which is more direct, involves, as a key step, the reduction of chiral oxazolidines or imines derived from ethyl trifluoropyruvate.

引用

页码：4540 / 4542

页数：3

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