Sirolimus-induced interstitial lung disease following pediatric stem cell transplantation

被引：5
|
作者：
Garrod, Andrea S. [1 ]
Goyal, Rakesh K. [2 ]
Weiner, Daniel J. [3 ,4 ,5 ]
机构：
[1] Univ Virginia, Dept Pediat, Div Pediat Resp Med, Charlottesville, VA USA
[2] UPMC, Childrens Hosp Pittsburgh, Blood & Marrow Transplantat & Cellular Therapies, Dept Pediat, Pittsburgh, PA USA
[3] UPMC, Childrens Hosp Pittsburgh, Div Pulm Med, Dept Pediat, Pittsburgh, PA USA
[4] UPMC, Childrens Hosp Pittsburgh, Div Allergy, Dept Pediat, Pittsburgh, PA USA
[5] UPMC, Childrens Hosp Pittsburgh, Div Immunol, Dept Pediat, Pittsburgh, PA USA
来源：
PEDIATRIC TRANSPLANTATION | 2015年 / 19卷 / 03期
关键词：
pediatrics; hematopoietic stem cell transplantation; sirolimus; interstitial lung disease; lung function tests; PULMONARY TOXICITY; PNEUMONITIS; INFANTS;
D O I：
10.1111/petr.12438
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Sirolimus-induced ILD is a known but rare complication in adults who have undergone SOT. However, little is known about this adverse effect in children. Diagnosis of sirolimus-induced ILD can be challenging, especially in patients who have difficulty participating in lung function testing. We present a case of presumed sirolimus-induced ILD in a pediatric stem cell transplant patient who developed polycythemia and hypoxemia. To our knowledge, no other cases of sirolimus-induced pulmonary toxicity in children after HCT have been reported.
引用
收藏
页码：E75 / E77
页数：3
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