Terpenes from the gum resin of Boswellia carterii and their NO inhibitory activies

被引：19
|
作者：
Yu, Jin-Qian [1 ]
Geng, Yan-Ling [1 ]
Wang, Dai-Jie [1 ]
Zhao, Hong-Wei [2 ]
Guo, Lanping [1 ]
Wang, Xiao [1 ,2 ]
机构：
[1] Qilu Univ Technol, Shandong Acad Sci, Shandong Anal & Test Ctr, Shandong Key Lab TCM Qual Control Technol, Jinan 250014, Shandong, Peoples R China
[2] Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250014, Shandong, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2018年 / 28卷
关键词：
Boswellia carterii; Diterpenoid; Dinortirucallane; Triterpene; Anti-inflammatory; OLIBANUM; TRITERPENES; ACIDS;
D O I：
10.1016/j.phytol.2018.09.010
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Three new terpenes, classified as one cembrane-type diterpenoid (rel)-(1S,5R,7E,11E)-1-isopropyl-8,12-dimethyl-4-methylenecyclotetradeca-7,11-diene-1,5-diol (1), one dinortirucallane-type triterpene 20,21-dinortirucalla-8,24-diene-3 beta-ol-7-one (2) and one ursane type triterpene 21 beta-hydroxy-3-O-acetyl-11-keto boswellic acid (3), respectively, along with four known triterpenes, were isolated from the gum resin of Boswellia carterii. Their structure elucidations were achieved by in-depth spectroscopic examination, mainly including experiments and analyses of multiple 1D- and 2D-NMR and HR-ESI-MS. The effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW264.7 cells of all the isolated compounds were evaluated in vitro. Compound 1, 4, 5 and 7 exhibited potent inhibitory effects on NO production with IC50 values of 1.32, 3.04, 1.42, and 3.25 mu M.
引用
收藏
页码：59 / 63
页数：5
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