Association of the upregulated expression of focal adhesion kinase with poor prognosis and tumor dissemination in hypopharyngeal cancer

被引：12
|
作者：
Omura, Go [1 ]
Ando, Mizuo [1 ]
Saito, Yuki [1 ]
Kobayashi, Kenya [1 ,2 ]
Yoshida, Masafumi [1 ]
Ebihara, Yasuhiro [1 ,3 ]
Kanaya, Kaori [1 ]
Fujimoto, Chisato [1 ]
Sakamoto, Takashi [1 ]
Kondo, Kenji [1 ]
Asakage, Takahiro [1 ,4 ]
Yamasoba, Tatsuya [1 ]
机构：
[1] Univ Tokyo, Dept Otolaryngol Head & Neck Surg, Fac Med, Tokyo, Japan
[2] Natl Canc Ctr, Dept Head & Neck Surg, Tokyo, Japan
[3] Saitama Med Univ, Dept Head & Neck Surg, Int Med Ctr, Saitama, Japan
[4] Tokyo Med & Dent Univ, Dept Head & Neck Surg, Tokyo, Japan
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2016年 / 38卷 / 08期
关键词：
focal adhesion kinase; hypopharyngeal cancer; immunohistochemistry; prognostic factor; pharyngectomy; SQUAMOUS-CELL CARCINOMA; LYMPH-NODE METASTASIS; FAK OVEREXPRESSION; SHORTER SURVIVAL; P53; MUTATIONS; NECK-CANCER; HEAD; PROGRESSION; SURGERY;
D O I：
10.1002/hed.24176
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
BackgroundFocal adhesion kinase (FAK) plays an important role in tumor metastasis. The purpose of this study was to evaluate the significance of FAK expression in surgically treated patients with hypopharyngeal cancer. MethodsWe retrospectively reviewed the clinical charts of patients treated at our institution between 2004 and 2012 and identified 87 patients with hypopharyngeal cancer. FAK expression status was retrospectively evaluated using immunohistochemistry. ResultsFAK-positive patients displayed significantly worse disease-specific survival than FAK-negative patients (p=.001). Multivariate analyses revealed that FAK positivity and extracapsular spread (ECS) were independent, significant adverse prognostic factors. Furthermore, FAK positivity significantly correlated with the number of metastatic lymph nodes (p=.048), and FAK-positive patients displayed a higher incidence of distant metastases (p=.009). ConclusionThe current study demonstrated that upregulated FAK expression correlates with poor prognosis and tumor dissemination in surgically treated patients with hypopharyngeal cancer. (c) 2016 Wiley Periodicals, Inc. Head Neck 38:1164-1169, 2016
引用
收藏
页码：1164 / 1169
页数：6
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