Activation of the mTOR/HIF-1α/VEGF axis promotes M1 macrophage polarization in non-eosCRSwNP

被引:12
|
作者
Zhong, Bing [1 ]
Du, Jintao [1 ]
Liu, Feng [1 ]
Liu, Yafeng [1 ]
Liu, Shixi [1 ]
Xie, Lifeng [2 ]
Wang, Deyun [3 ]
Ba, Luo [2 ]
机构
[1] Sichuan Univ, West China Hosp, Dept Otolaryngol Head & Neck Surg, Upper Airways Res Lab, Chengdu, Sichuan, Peoples R China
[2] Peoples Hosp Tibet Autonomous Reg, Dept Otolaryngol, 18 Lingo North Rd, Lhasa 850000, Peoples R China
[3] Natl Univ Hlth Syst, Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Otolaryngol, Singapore, Singapore
基金
中国国家自然科学基金;
关键词
chronic rhinosinusitis with nasal polyps; Hypoxia-induced factor-1 alpha; macrophage; mammalian target of rapamycin; vascular endothelial growth factor;
D O I
10.1111/all.15050
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:643 / 646
页数:4
相关论文
共 50 条
  • [31] Chemerin promotes the pathogenesis of preeclampsia by activating CMKLR1/p-Akt/CEBPɑ axis and inducing M1 macrophage polarization
    Zhi-Song Ji
    Hua Jiang
    Yue Xie
    Qi-Peng Wei
    Xiao-Fang Yin
    Jin-Hai Ye
    Xiao-Zhen Quan
    Yan-Li Lan
    Meng Zhao
    Xiao-Long Tian
    Ya-Jun Zhang
    Xue-Zhou Yang
    Cell Biology and Toxicology, 2022, 38 : 611 - 628
  • [32] Chemerin promotes the pathogenesis of preeclampsia by activating CMKLR1/p-Akt/CEBPalpha axis and inducing M1 macrophage polarization
    Ji, Zhi-Song
    Jiang, Hua
    Xie, Yue
    Wei, Qi-Peng
    Yin, Xiao-Fang
    Ye, Jin-Hai
    Quan, Xiao-Zhen
    Lan, Yan-Li
    Zhao, Meng
    Tian, Xiao-Long
    Zhang, Ya-Jun
    Yang, Xue-Zhou
    CELL BIOLOGY AND TOXICOLOGY, 2022, 38 (04) : 611 - 628
  • [33] Prodrug of epigallocatechin-3-gallate alleviates choroidal neovascularization via down-regulating HIF-1α/VEGF/VEGFR2 pathway and M1 type macrophage/microglia polarization
    Xu, Jiaowen
    Tu, Yuanyuan
    Wang, Ying
    Xu, Xun
    Sun, Xiaodong
    Xie, Laiqing
    Zhao, Qingliang
    Guo, Yang
    Gu, Yonghui
    Du, Jingxia
    Du, Shu
    Zhu, Manhui
    Song, E.
    BIOMEDICINE & PHARMACOTHERAPY, 2020, 121
  • [34] HIF-1α increases the osteogenic capacity of ADSCs by coupling angiogenesis and osteogenesis via the HIF-1α/VEGF/AKT/mTOR signaling pathway
    Shuang Song
    Guanhua Zhang
    Xutao Chen
    Jian Zheng
    Xiangdong Liu
    Yiqing Wang
    Zijun Chen
    Yuxi Wang
    Yingliang Song
    Qin Zhou
    Journal of Nanobiotechnology, 21
  • [35] TRAM1 Promotes Microglia M1 Polarization
    Hanxiang Wang
    Chun Liu
    Ming Han
    Chun Cheng
    Dongmei Zhang
    Journal of Molecular Neuroscience, 2016, 58 : 287 - 296
  • [36] TRAM1 Promotes Microglia M1 Polarization
    Wang, Hanxiang
    Liu, Chun
    Han, Ming
    Cheng, Chun
    Zhang, Dongmei
    JOURNAL OF MOLECULAR NEUROSCIENCE, 2016, 58 (02) : 287 - 296
  • [37] Tiliroside Ameliorates Ulcerative Colitis by Restoring the M1/M2 Macrophage Balance via the HIF-1α/glycolysis Pathway
    Zhuang, Hongda
    Lv, Qi
    Zhong, Chao
    Cui, Yaru
    He, Luling
    Zhang, Cheng
    Yu, Jun
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [38] Histone methyltransferase SETD2 inhibits M1 macrophage polarization and glycolysis by suppressing HIF-1α in sepsis-induced acute lung injury
    Yan Meng
    Kai-wen Kong
    Yong-qing Chang
    Xiao-ming Deng
    Tao Yang
    Medical Microbiology and Immunology, 2023, 212 : 369 - 379
  • [39] AhR activation attenuates calcium oxalate nephrocalcinosis by diminishing M1 macrophage polarization and promoting M2 macrophage polarization
    Yang, Xiaoqi
    Liu, Haoran
    Ye, Tao
    Duan, Chen
    Lv, Peng
    Wu, Xiaoliang
    Liu, Jianhe
    Jiang, Kehua
    Lu, Hongyan
    Yang, Huan
    Xia, Ding
    Peng, Ejun
    Chen, Zhiqiang
    Tang, Kun
    Ye, Zhangqun
    THERANOSTICS, 2020, 10 (26): : 12011 - 12025
  • [40] Auraptene Promotes THP-1 Polarization to M1 Macrophages and Improves M1 Function
    Jalali, Afshin
    Hoseini, Mostafa Haji Molla
    Rezaei, Mitra
    Ziai, Seyed Ali
    RESEARCH JOURNAL OF PHARMACOGNOSY, 2022, 9 (01) : 63 - 75