Activation of the mTOR/HIF-1α/VEGF axis promotes M1 macrophage polarization in non-eosCRSwNP

被引:12
|
作者
Zhong, Bing [1 ]
Du, Jintao [1 ]
Liu, Feng [1 ]
Liu, Yafeng [1 ]
Liu, Shixi [1 ]
Xie, Lifeng [2 ]
Wang, Deyun [3 ]
Ba, Luo [2 ]
机构
[1] Sichuan Univ, West China Hosp, Dept Otolaryngol Head & Neck Surg, Upper Airways Res Lab, Chengdu, Sichuan, Peoples R China
[2] Peoples Hosp Tibet Autonomous Reg, Dept Otolaryngol, 18 Lingo North Rd, Lhasa 850000, Peoples R China
[3] Natl Univ Hlth Syst, Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Otolaryngol, Singapore, Singapore
基金
中国国家自然科学基金;
关键词
chronic rhinosinusitis with nasal polyps; Hypoxia-induced factor-1 alpha; macrophage; mammalian target of rapamycin; vascular endothelial growth factor;
D O I
10.1111/all.15050
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:643 / 646
页数:4
相关论文
共 50 条
  • [1] Activation of the JNK/COX-2/HIF-1α axis promotes M1 macrophage via glycolytic shift in HIV-1 infection
    Zhang, Junhan
    Yuan, Zongxiang
    Li, Xuanrong
    Wang, Fengyi
    Wei, Xueqin
    Kang, Yiwen
    Mo, Chuye
    Jiang, Junjun
    Liang, Hao
    Ye, Li
    LIFE SCIENCE ALLIANCE, 2023, 6 (12)
  • [2] Axl promotes intracranial aneurysm rupture by regulating macrophage polarization toward M1 via STAT1/HIF-1α
    Han, Yongquan
    Li, Gaozhi
    Zhang, Zeyu
    Zhang, Xiaohua
    Zhao, Bing
    Yang, Hua
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [4] SENP3 facilitates M1 macrophage polarization via the HIF-1α/PKM2 axis in lipopolysaccharide-induced acute lung injury
    He, Shuangjun
    Fan, Chenyu
    Ji, Yiming
    Su, Qian
    Zhao, Feng
    Xie, Cuiying
    Chen, Xuelian
    Zhang, Yang
    Chen, Yi
    INNATE IMMUNITY, 2023, 29 (1-2) : 25 - 34
  • [5] Sucralose promotes pro-inflammatory M1 macrophage polarization
    Aurora Stephens-Camacho, N.
    Rosas Rodriguez, Jesus A.
    Islas-Zamorano, Anna P.
    Magana-Gomez, Javier A.
    Flores-Mendoza, Lilian K.
    REVISTA CHILENA DE NUTRICION, 2022, 49 (05): : 578 - 587
  • [6] mTOR信号通路调节HIF-1α及VEGF
    陈洪菊
    唐彬秩
    屈艺
    母得志
    生命的化学, 2011, 31 (06) : 838 - 843
  • [7] Itraconazole Promotes Macrophage M1 Polarization and Phagocytic Capacity of Macrophage to Candida Albicans
    Zheng Xiao-Li
    Liang Guan-Zhao
    Shi Dong-Mei
    Yao Hui-Ping
    Zhang Lu
    Liu Wei-Da
    Chen Guan-Zhi
    国际皮肤性病学杂志(英文), 2019, 2 (04) : 193 - 201
  • [8] Advanced glycation end products enhance macrophage polarization to the M1 phenotype via the HIF-1α/PDK4 pathway
    Han, Xiqiong
    Ma, Wenqi
    Zhu, Yi
    Sun, Xuejiao
    Liu, Naifeng
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2020, 514
  • [9] An AMPK agonist suppresses the progress of colorectal cancer by regulating the polarization of TAM to M1 through inhibition of HIF-1α and mTOR signal pathway
    Cao, Yuanyuan
    Wo, Mingyi
    Xu, Chan
    Fei, Xianming
    Jin, Juan
    Shan, Zhiming
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2023, 19 (06) : 1560 - 1567
  • [10] Aerobic Glycolysis Induced by mTOR/HIF-1α Promotes Early Brain Injury After Subarachnoid Hemorrhage via Activating M1 Microglia
    Xin-Gang Sun
    Xue-Hong Chu
    Ivan Steve Godje Godje
    Shao-Yu Liu
    Hui-Yu Hu
    Yi-Bo Zhang
    Li-Juan Zhu
    Hai Wang
    Chen Sui
    Juan Huang
    Ying-Jie Shen
    Translational Stroke Research, 2024, 15 : 1 - 15