WITHDRAWAL OF ADALIMUMAB IN EARLY RHEUMATOID ARTHRITIS PATIENTS WHO ATTAINED STABLE LOW DISEASE ACTIVITY WITH ADALIMUMAB PLUS METHOTREXATE: RESULTS OF A PHASE 4, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

被引:0
|
作者
Kavanaugh, Arthur [1 ]
Emery, Paul [2 ]
Fleischmann, Roy [3 ]
van Vollenhoven, Ronald [4 ]
Pavelka, Karel [5 ]
Durez, Patrick [6 ]
Guerette, Benoit [7 ]
Santra, Sourav [8 ]
Redden, Laura [8 ]
Kupper, Hartmut [9 ]
Smolen, Josef S. [10 ,11 ]
机构
[1] Univ Calif San Diego, Div Rheumatol Allergy & Immunol, La Jolla, CA 92093 USA
[2] Leeds Teaching Hosp, Dept Rheumatol, Leeds, W Yorkshire, England
[3] Univ Texas SW Med Ctr Dallas, Dept Rheumatol, Dallas, TX 75390 USA
[4] Karolinska Inst, Dept Rheumatol, Stockholm, Sweden
[5] Charles Univ Prague, Dept Rheumatol, Prague, Czech Republic
[6] Catholic Univ Louvain, Dept Rheumatol, B-1348 Louvain, Belgium
[7] Abbott, GPRD, Rungis, France
[8] Abbott, GPRD, Abbott Pk, IL USA
[9] Abbott, GPRD, Ludwigshafen, Germany
[10] Med Univ Vienna, Dept Rheumatol, Vienna, Austria
[11] Hietzing Hosp, Vienna, Austria
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:29 / 30
页数:2
相关论文
共 50 条
  • [41] Sarilumab plus methotrexate in patients with active rheumatoid arthritis and inadequate response to methotrexate: results of a randomized, placebo-controlled phase III trial in Japan
    Tanaka, Yoshiya
    Wada, Kazuteru
    Takahashi, Yoshinori
    Hagino, Owen
    van Hoogstraten, Hubert
    Graham, Neil M. H.
    Kameda, Hideto
    ARTHRITIS RESEARCH & THERAPY, 2019, 21 (1)
  • [42] Sarilumab plus methotrexate in patients with active rheumatoid arthritis and inadequate response to methotrexate: results of a randomized, placebo-controlled phase III trial in Japan
    Yoshiya Tanaka
    Kazuteru Wada
    Yoshinori Takahashi
    Owen Hagino
    Hubert van Hoogstraten
    Neil M. H. Graham
    Hideto Kameda
    Arthritis Research & Therapy, 21
  • [43] INTRAVENOUS GOLIMUMAB IS EFFECTIVE IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS DESPITE METHOTREXATE THERAPY WITH RESULTS OBSERVED BY 2 WEEKS: RESULTS OF THE PHASE 3, MULTICENTER, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL
    Weinblatt, M. E.
    Bingham, C. O., III
    Mendelsohn, A. M.
    Kim, L.
    Mack, M.
    Lu, J.
    Baker, D.
    Westhovens, R.
    ANNALS OF THE RHEUMATIC DISEASES, 2013, 71 : 368 - 369
  • [44] Efficacy and safety of tofacitinib monotherapy, tofacitinib with methotrexate, and adalimumab with methotrexate in patients with rheumatoid arthritis (ORAL Strategy): a phase 3b/4, double-blind, head-to-head, randomised controlled trial
    Fleischmann, Roy
    Mysler, Eduardo
    Hall, Stephen
    Kivitz, Alan J.
    Moots, Robert J.
    Luo, Zhen
    DeMasi, Ryan
    Soma, Koshika
    Zhang, Richard
    Takiya, Liza
    Tatulych, Svitlana
    Mojcik, Christopher
    Krishnaswami, Sriram
    Menon, Sujatha
    Smolen, Josef S.
    LANCET, 2017, 390 (10093): : 457 - 468
  • [45] Adjustment of therapy in rheumatoid arthritis on the basis of achievement of stable low disease activity with adalimumab plus methotrexate or methotrexate alone: the randomised controlled OPTIMA trial (vol 383, pg 321, 2014)
    Smolen, J. S.
    Emery, P.
    Fleischmann, R.
    LANCET, 2014, 383 (9914): : 308 - 308
  • [46] SUPPLEMENTATION WITH FOLIC-ACID DARING METHOTREXATE THERAPY FOR RHEUMATOID-ARTHRITIS - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL
    MORGAN, SL
    BAGGOTT, JE
    VAUGHN, WH
    AUSTIN, JS
    VEITCH, TA
    LEE, JY
    KOOPMAN, WJ
    KRUMDIECK, CL
    ALARCON, GS
    ANNALS OF INTERNAL MEDICINE, 1994, 121 (11) : 833 - 841
  • [47] SINGLE INFUSION WITH APD IN PATIENTS WITH ACTIVE RHEUMATOID-ARTHRITIS - A DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL
    EGGELMEIJER, F
    PAPAPOULOS, S
    DIJKMANS, B
    BREEDVELD, F
    ARTHRITIS AND RHEUMATISM, 1993, 36 (09): : S57 - S57
  • [48] Inhibition of Joint Destruction in Patients with Rheumatoid Arthritis Treated with Peficitinib in Combination with Methotrexate: A Randomized, Double-Blind, Placebo-Controlled Trial in Japan
    Takeuchi, Tsutomu
    Tanaka, Yoshiya
    Rokuda, Mitsuhiro
    Izutsu, Hiroyuki
    Kaneko, Yuichiro
    Fukuda, Musashi
    Kato, Daisuke
    van der Heijde, Desiree
    ARTHRITIS & RHEUMATOLOGY, 2019, 71
  • [49] The AMPK modulator metformin as adjunct to methotrexate in patients with rheumatoid arthritis: A proof-of-concept, randomized, double-blind, placebo-controlled trial
    Abdallah, Mahmoud S.
    Alarfaj, Sumaiah J.
    Saif, Dalia S.
    El-Naggar, Mostafa E.
    Elsokary, Mohamed A.
    Elsawah, Hozaifa K.
    Zaki, Shimaa Abdelsattar
    Wahsh, Engy A.
    Mansour, Hend E. Abo
    Mosalam, Esraa M.
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 95
  • [50] Diacerein for the treatment of rheumatoid arthritis in patients with inadequate response to methotrexate: a pilot randomized, double-blind, placebo-controlled add-on trial
    Louthrenoo, Worawit
    Nilganuwong, Surasak
    Nanagara, Ratanavadee
    Siripaitoon, Boonjing
    Basset, Sabine Collaud
    CLINICAL RHEUMATOLOGY, 2019, 38 (09) : 2461 - 2471