SUBSTITUTED 2-AMINONICOTINAMIDES IN THE SYNTHESIS OF PYRIDO[2,3-d]PYRIMIDIN-4(1H)-ONES, 2,3-DIHYDROPYRIDO-[2,3-d]PYRIMIDIN-4(1H)-ONES, AND 11b,12-DIHYDROPYRIDO-[2′,3′:4,5]PYRIMIDO[2,1-a]ISOINDOLE-5,7-DIONES

被引：3

作者：

Sidorova, E. A. ^{[2
]}

Kostenko, E. S. ^{[2
]}

Arustamova, I. S. ^{[2
]}

Kaigorodova, E. A. ^{[2
]}

Konyushkin, L. D. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia

[2] Kuban State Agr Univ, Krasnodar 350044, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2011年 / 47卷 / 03期

关键词：

2-aminonicotinamides; 2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-ones; pyrido[2,3-d]pyrimidin-4(1H)-ones; 5,7,11b,12-tetrahydropyrido[2 ',3 ':4,5]-pyrimido[2,1-a]isoindole-5,7-diones; heterocyclization;

D O I：

10.1007/s10593-011-0756-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reactions of 2-aminonicotinamides with triethyl orthoformate, carboxylic acids chlorides, aldehydes, and 2-formylbenzoic acid were studied. As a result pyrido[2,3-d]pyrimidin-4(1H)-ones, 2,3-dihydropyrido[2,3-d]pyrimidin-4(1H)-ones, and 5,7,11b,12-tetrahydropyrido[2',3':4,5]pyrimido-[2,1-a]isoindole-5,7-diones were obtained.

引用

页码：294 / 301

页数：8

共 50 条

[21] Efficient synthesis of 2-substituted thieno[2,3-d]pyrimidin-4(3H)-ones via an iminophosphorane
Fang, Zheng-Dong
Hu, Yang-Gen
Ding, Ming-Wu
HETEROATOM CHEMISTRY, 2008, 19 (03) : 266 - 270
[22] Synthesis of 4-substituted pyrido[2,3-d]pyrimidin-4(1H)-one as analgesic and anti-inflammatory agents
El-Gazzar, Abdel-Rahman B. A.
Hafez, Hend N.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (13) : 3392 - 3397
[23] Derivatives of the condensed thieno[2,3-d]pyrimidines.: 20.: Synthesis of 2-substituted 5,6-dihydro-8H-pyrano[4′,3′:4,5]thieno[2,3-d]pyrimidin-4(3H)-ones and 5,6,7,8-tetrahydrobenzo[b]thieno[2,3-d]pyrimidin-4(3H)-ones
Mkrtchyan, AP
Noravyan, AS
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 2006, (03): : 441 - 444
[24] A CONVENIENT PROCEDURE FOR THE PREPARATION OF 5,6-DIHYDRO-6-NITRO-5-PHENYLFURO[2,3-D]PYRIMIDIN-4(3H)-ONES AND 5-PHENYLFURO[2,3-D]PYRIMIDIN-4(3H)-ONES
DAUZONNE, D
ADAMLAUNAY, A
TETRAHEDRON, 1992, 48 (15) : 3069 - 3080
[25] SYNTHESIS OF 2-AMINO AND 2-GUANIDINO-THIENO[2,3-D]PYRIMIDIN-4(3H)-ONES
RAJASEKHARAN, KN
THOMAS, L
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1983, 22 (01): : 76 - 77
[26] SYNTHESIS AND PHARMACOLOGICAL STUDY OF ANTIHYPERLIPAEMIC ACTIVITY OF 2-SUBSTITUTED THIENO(2,3-D)PYRIMIDIN-4(3H)-ONES
SHISHOO, CJ
DEVANI, MB
BHADTI, VS
JAIN, KS
RATHOD, IS
GOYAL, RK
GANDHI, TP
PATEL, RB
NAIK, SR
ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1990, 40-1 (05): : 567 - 572
[27] A Convenient One-pot Synthesis of 2,3-Disubstituted Thieno[2,3-d] pyrimidin-4(3H)-ones from 2H-Thieno[2,3-d][1,3] oxazine2,4(1H)-diones, Aromatic Aldehydes and Amines
Liu, Feize
Hou, Xueling
Nie, Li Fei
Bozorov, Khurshed
Decker, Michael
Huang, Guozheng
SYNOPEN, 2018, 2 (02): : 207 - 212
[28] Synthesis and evaluation of thieno[2,3-d]pyrimidin-4(3H)-ones as potential antitubercular agents
Borate, Hanumant B.
Annadate, Ritesh A.
Vagh, Sandip S.
Pisal, Mahesh M.
Deokate, Sagar B.
Arkile, Manisha A.
Jadhav, Nandadeep J.
Nawale, Laxman U.
Sarkar, Dhiman
MEDCHEMCOMM, 2015, 6 (12) : 2209 - 2215
[29] Base-catalyzed synthesis of 2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones and isolation of intermediates using microwave irradiation
Davoodnia, A.
Bakavoli, M.
Zareei, N.
Tavakoli-Hoseini, N.
BULGARIAN CHEMICAL COMMUNICATIONS, 2009, 41 (03): : 226 - 229
[30] Derivatives of condensed thieno[2,3-d]-pyrimidines. 20. Synthesis of 2-substituted 5,6-dihydro-8H-pyrano[4′,3′:4,5]thieno[2,3-d] pyrimidin-4(3H)-ones and 5,6,7,8-tetrahydrobenzo-[b]thieno[2,3-d]pyrimidin-4- ones
Mkrtchyan A.P.
Noravyan A.S.
Chem. Heterocycl. Compd., 2006, 3 (392-395): : 392 - 395

← 1 2 3 4 5 →