The Effect of Clostridioides difficile Diagnostic Stewardship Interventions on the Diagnosis of Hospital-Onset Clostridioides difficile Infections

Background: Public reporting of Clostridioides difficile infection (CDI) using laboratory-identified events has led some institutions to revert from molecular-based tests to less sensitive testing modalities. At one academic medical center, researchers chose to use nucleic acid amplification test alone in CDI diagnosis with institutional protocols aimed at diagnostic stewardship. Methods: A single-center, quasi-experimental study was conducted to introduce and analyze the effects of various diag-nostic stewardship interventions. In April 2017 an order report was created to inform providers of patients' recent bowel movements, laxative use, and prior Clostridioides difficile (CD) testing (Intervention 1). In November 2017 nursing staff were empowered to not send nondiarrheal stools for testing (Intervention 2). In February 2019, an interruptive alert was implemented to prevent testing that was not indicated (Intervention 3). CD testing rates and healthcare facility-onset CDI (HO-CDI) rates were compared before and after the interventions using one-way analysis of variance (ANOVA). Results: At baseline, testing for CD after 3 days of admission was performed at mean +/- standard deviation of 15.9 +/- 1.7 tests/1,000 patient-days. After Intervention 1, it decreased to 12.1 +/- 1.1 tests. This further decreased to 10.6 +/- 0.8 after Intervention 2 and to 8.1 +/- 0.1 after Intervention 3 (p < 0.001). HO-CDI cases per 10,000 patient-days declined from 12.7 +/- 1.4 cases at baseline to 10.7 +/- 1.2 after Intervention 1, to 8.7 +/- 2.4 after Intervention 2, and to 5.8 +/- 0.2 after Intervention 3 (p = 0.03). Conclusion: A multidisciplinary approach optimizing electronic health record support tools and leveraging nursing edu-cation can reduce both testing and HO-CDI rates while using the most sensitive testing modality.