Bacterial Reductionism: Host Thiols Enhance Virulence

被引：1
|
作者：
Sperandio, Vanessa [1 ,2 ]
机构：
[1] Univ Texas SW Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA
[2] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA
来源：
CELL HOST & MICROBE | 2015年 / 18卷 / 01期
关键词：
BURKHOLDERIA-PSEUDOMALLEI; INTRACELLULAR PATHOGEN; GLUTATHIONE; SYSTEM;
D O I：
10.1016/j.chom.2015.06.010
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Intracellular bacteria exploit host cytosolic signals to upregulate virulence genes. In this issue of Cell Host & Microbe, Wong et al. (2015) show that Burkholderia pseudomallei senses host cytosolic glutathione, a low-molecular-weight thiol, through the membrane-bound histidine sensor kinase VirA, highlighting the importance of inter-kingdom signaling in bacterial pathogenesis.
引用
收藏
页码：7 / 8
页数：2
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