A comparative study of the effect of a gentle ketogenic diet containing medium-chain or long-chain triglycerides on chronic sleep deprivation-induced cognitive deficiency

被引：0
|
作者：
Wang, Xueyan [1 ]
Yang, Yueqi [1 ]
Xiao, Aiai [1 ]
Zhang, Ning [1 ]
Miao, Mingyong [1 ,2 ]
Wang, Zhengping [1 ,3 ]
Han, Jun [1 ,3 ]
Wen, Min [1 ]
机构：
[1] Liaocheng Univ, Inst Biopharmaceut Res, Liaocheng 252059, Shandong, Peoples R China
[2] Second Mil Med Univ, Coll Basic Med Sci, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China
[3] Liaocheng High Tech Biotechnol Co Ltd, Liaocheng 252059, Shandong, Peoples R China
来源：
FOOD & FUNCTION | 2022年 / 13卷 / 04期
基金：
中国国家自然科学基金;
关键词：
FEEDBACK LOOP; BRAIN; MEMORY; BDNF; RESTRICTION; NRF2; HIPPOCAMPUS; SENSITIVITY; METABOLISM; ALPHA;
D O I：
10.1039/d1fo04087a
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The ketogenic diet (KD) is well known for its neuroprotective effect, but little is known about its prophylactic efficacy against chronic sleep deprivation (SD) induced cognitive deficiency. An emerging study indicated that ferroptosis plays an important role in neurologic diseases but has been rarely reported in chronic SD. Here, we investigated the prophylactic effects of a medium-chain triglyceride-enriched KD (MKD) and a long-chain triglyceride-enriched KD (LKD) on cognitive deficiency and revealed the underlying mechanism focused on ferroptosis in chronic SD model mice. The results showed that the MKD exhibited stronger effects than the LKD on improving cognitive deficiency via suppressing ferroptosis and improving synaptic plasticity. Further mechanism results indicated that MKD produced higher Sirt3 protein levels than LKD, which probably contributed to the synergistic effect of beta hydroxybutyric acid and decanoic acid. Our finds provide novel evidence for the KD as a safe and feasible dietary intervention to prevent chronic SD-induced cognitive deficiency, and suggest a better choice of medium-chain fatty acid-enriched KD.
引用
收藏
页码：2283 / 2294
页数：12
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