Single-agent panobinostat for relapsed/refractory diffuse large B-cell lymphoma: clinical outcome and correlation with genomic data. A phase 2 study of the Fondazione Italiana Linfomi

被引：13

作者：

Zaja, Francesco ^{[1
,2
]}

Salvi, Flavia ^{[3
]}

Rossi, Maura ^{[4
]}

Sabattini, Elena ^{[5
]}

Evangelista, Andrea ^{[5
]}

Ciccone, Giovannino ^{[6
,7
]}

Angelucci, Emanuele ^{[8
]}

Gaidano, Gianluca ^{[9
]}

Zanni, Manuela ^{[9
]}

Ladetto, Marco ^{[3
]}

Chiappella, Annalisa ^{[10
]}

Vitolo, Umberto ^{[10
]}

Zinzani, Pier Luigi ^{[11
]}

Califano, Catello ^{[12
]}

Tucci, Alessandra ^{[13
,14
]}

Patti, Caterina ^{[15
]}

Pileri, Stefano A. ^{[16
]}

Lenti, Valentina ^{[17
]}

Piccaluga, Pier Paolo ^{[4
]}

Cavallo, Federica ^{[18
]}

Volpetti, Stefano ^{[19
,20
]}

Perali, Giulia ^{[19
,20
]}

Assouline, Sarit ^{[21
]}

Mann, Koren Kathleen ^{[22
]}

Morin, Ryan ^{[23
]}

Alcaide, Miguel ^{[23
]}

Bushell, Kevin ^{[23
]}

Fanin, Renato ^{[1
,2
]}

Levis, Alessandro ^{[17
]}

机构：

[1] Univ Udine, Clin Ematol, DAME, Udine, Italy

[2] Univ Udine, Unita Terapie Cellulari Carlo Melzi, DAME, Udine, Italy

[3] AO SS Antonio & Biagio & C Arrigo, SC Ematol, Alessandria, Italy

[4] Univ Hosp Bologna, Unit Haemolymphopathol, Dept Expt Diagnost & Specialty Med, Bologna, Italy

[5] Univ Hosp Bologna, Dept Hematol & Oncol, Unit Haemolymphopathol, Bologna, Italy

[6] AOU Citta Salute & Sci Torino, Unit Clin Epidemiol, Turin, Italy

[7] CPO Piemonte, Turin, Italy

[8] IRCCS AOU San Martino IST, UOC Ematol, Genoa, Italy

[9] Amedeo Avogadro Univ Eastern Piedmont, Dept Translat Med, Div Hematol, Novara, Italy

[10] AOU Citta Salute & Sci, SC Ematol, Turin, Italy

[11] Univ Bologna, Inst Hematol L&A Seragnoli, Bologna, Italy

[12] Osped Umberto I, UO Med Oncoematol, Nocera Inferiore, Italy

[13] Spedali Civil Brescia, SC Ematol, Brescia, Italy

[14] Spedali Civil Brescia, Dipartimento Oncol Med, Brescia, Italy

[15] Osped V Cervello, UOC Ematol, Palermo, Italy

[16] Milano Univ, Sch Med, European Inst Oncol, Haematopathol Unit, Bologna, Italy

[17] Fdn Italiana Linfomi, Alessandria, Italy

[18] Univ Torino, Azienda Osped Univ Citta Salute & Sci, Turin, Italy

[19] Azienda Sanit Univ Integrata, Clin Ematol, Udine, Italy

[20] Azienda Sanit Univ Integrata, Unita Terapie Cellulari Carlo Melzi, Udine, Italy

[21] McGill Univ, Jewish Gen Hosp, Div Hematol, Montreal, PQ, Canada

[22] McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada

[23] Simon Fraser Univ, Dept Mol Biol & Biochem, Sch Comp Sci, Vancouver, BC, Canada

来源：

LEUKEMIA & LYMPHOMA | 2018年 / 59卷 / 12期

关键词：

Diffuse large B-cell lymphoma; panobinostat; relapsed/refractory; genomic; DEACETYLASE INHIBITOR PANOBINOSTAT; HISTONE DEACETYLASES; RITUXIMAB; DISEASE; MULTICENTER; ROMIDEPSIN; MUTATION; LBH589; TRIAL; CHOP;

D O I：

10.1080/10428194.2018.1452208

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated panobinostat 40 mg three times weekly in 35 adult patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL). Overall response rate and complete response were 17.1% and 11.4%, respectively. Median progression-free survival (PFS) and overall survival were 2.4 and 7.6 months, respectively. Calculated 12, 24 and 36 months PFS were 26%, 11% and 11%, respectively. Four patients who achieved a sustained CR, continued receiving panobinostat for an overall period of 44, 48, 50, 62 months. Thrombocytopenia grade 3 (5 patients) and 4 (24 patients) represented the main toxic effect, causing dose reduction or treatment suspension in 19 patients. Genomic analysis was unable to identify any relationship between mutations and response; TP53 mutation appeared not to impact the clinical outcome. Overall, panobinostat has a modest activity in R/R DLBCL patients, however it can induce very long lasting responses in some cases. Thrombocytopenia frequently limits the use of this agent.

引用

页码：2904 / 2910

页数：7

共 50 条

[21] A Fondazione Italiana Linfomi cohort study of R-COMP vs R-CHOP in older patients with diffuse large B-cell lymphoma
Arcari, Annalisa
Rigacci, Lugi
Tucci, Alessandra
Puccini, Benedetta
Usai, Sara Veronica
Cavallo, Federica
Fabbri, Alberto
Balzarotti, Monica
Pelliccia, Sabrina
Luminari, Stefano
Pennese, Elsa
Zilioli, Vittorio Ruggero
Mahmoud, Abdurraouf Mokhtar
Musuraca, Gerardo
Marino, Dario
Sartori, Roberto
Botto, Barbara
Gini, Guido
Zanni, Manuela
Hohaus, Stefan
Tarantini, Giuseppe
Flenghi, Leonardo
Tani, Monica
Di Rocco, Alice
Merli, Michele
Vallisa, Daniele
Pagani, Chiara
Nassi, Luca
Dessi, Daniela
Ferrero, Simone
Cencini, Emanuele
Bernuzzi, Patrizia
Mammi, Caterina
Marcheselli, Luigi
Tabanelli, Valentina
Spina, Michele
Merli, Francesco
BLOOD ADVANCES, 2023, 7 (15) : 4160 - 4169
[22] INTERIM RESULTS OF A PHASE II STUDY OF FONDAZIONE ITALIANA LINFOMI ON GEMCITABINE PLUS ROMIDEPSIN IN RELAPSED/REFRACTORY PERIPHERAL T CELL LYMPHOMA PATIENTS
Pellegrini, C.
Broccoli, A.
Casadei, B.
Chiappella, A.
Corradini, P.
Derenzini, E.
Dodero, A.
Farina, L.
Gandolfi, L.
Ladetto, M.
Monaco, F.
Orsucci, L.
Quirini, F.
Salvi, F.
Spina, F.
Stefoni, V.
Tonialini, L.
Vitolo, U.
Argnani, L.
Cavo, M.
Zinzani, P. L.
HAEMATOLOGICA, 2015, 100 : 18 - 19
[23] Phase 2 Study of Daratumumab in Relapsed/Refractory Mantle-Cell Lymphoma, Diffuse Large B-Cell Lymphoma, and Follicular Lymphoma
Salles, Gilles
Gopal, Ajay K.
Minnema, Monique C.
Wakamiya, Karen
Feng, Huaibao
Schecter, Jordan M.
Wang, Michael
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 (05): : 275 - 284
[24] Biological features and outcome of diffuse large B-cell lymphoma associated with hepatitis C virus in elderly patients: Results of the prospective 'Elderly Project' by the Fondazione Italiana Linfomi
Arcari, Annalisa
Tabanelli, Valentina
Merli, Francesco
Marcheselli, Luigi
Merli, Michele
Balzarotti, Monica
Zilioli, Vittorio Ruggero
Fabbri, Alberto
Cavallo, Federica
Casaluci, Gloria Margiotta
Tucci, Alessandra
Puccini, Benedetta
Pennese, Elsa
Di Rocco, Alice
Zanni, Manuela
Flenghi, Leonardo
Gini, Guido
Sartori, Roberto
Chiappella, Annalisa
Usai, Sara Veronica
Tani, Monica
Marino, Dario
Arcaini, Luca
Vallisa, Daniele
Spina, Michele
BRITISH JOURNAL OF HAEMATOLOGY, 2023, 201 (04) : 653 - 662
[25] Copanlisib in Combination with Nivolumab in Subjects with Relapsed/Refractory Diffuse Large B-Cell Lymphoma and Primary Mediastinal Large B-Cell Lymphoma: A Phase 2 Study
Bennani, N. Nora
Nowakowski, Grzegorz
Rimsza, Lisa M.
Adjei, Alex A.
Doyle, Laurence
Ansell, Stephen M.
BLOOD, 2019, 134
[26] Single-Agent Pixantrone as a Bridge to Autologous Stem Cell Transplantation in a Patient with Refractory Diffuse Large B-Cell Lymphoma
Appio, Lorena
Landoni, Carlo
La Targia, Maria
Bertolli, Vanda
Chiarucci, Martina
Crovetti, Giovanni
Vassenna, Elisabetta
Serio, Giovanni
Bregni, Marco
CHEMOTHERAPY, 2017, 62 (03) : 187 - 191
[27] The Impact of Healthy Lifestyles on Late Sequelae in Classical Hodgkin Lymphoma and Diffuse Large B-Cell Lymphoma Survivors. A Systematic Review by the Fondazione Italiana Linfomi
Minoia, Carla
Gerardi, Chiara
Allocati, Eleonora
Daniele, Antonella
De Sanctis, Vitaliana
Bari, Alessia
Guarini, Attilio
CANCERS, 2021, 13 (13)
[28] Male and Female Fertility: Prevention and Monitoring Hodgkin' Lymphoma and Diffuse Large B-Cell Lymphoma Adult Survivors. A Systematic Review by the Fondazione Italiana Linfomi
Viviani, Simonetta
Caccavari, Valentina
Gerardi, Chiara
Ramadan, Safaa
Allocati, Eleonora
Minoia, Carla
Guarini, Attilio
Di Russo, Anna
CANCERS, 2021, 13 (12)
[29] Phase II Study of the Fondazione Italiana Linfomi on Gemcitabine Plus Romidepsin (GEMRO Regimen) in Relapsed and Refractory Peripheral T-Cell Lymphoma Patients
Pellegrini, Cinzia
Broccoli, Alessandro
Casadei, Beatrice
Chiappella, Annalisa
Corradini, Paolo
Derenzini, Enrico
Dodero, Anna
Farina, Lucia
Gandolfi, Letizia
Ladetto, Marco
Monaco, Federico
Orsucci, Lorella
Quirini, Federica
Salvi, Flavia
Spina, Francesco
Stefoni, Vittorio
Tonialini, Lorenzo
Vitolo, Umberto
Argnani, Lisa
Zinzani, Pier Luigi
BLOOD, 2015, 126 (23)
[30] Lenalidomide plus cyclophosphamide, doxorubicin, vincristine, prednisone and rituximab is safe and effective in untreated, elderly patients with diffuse large B-cell lymphoma: a phase I study by the Fondazione Italiana Linfomi
Chiappella, Annalisa
Tucci, Alessandra
Castellino, Alessia
Pavone, Vincenzo
Baldi, Ileana
Carella, Angelo Michele
Orsucci, Lorella
Zanni, Manuela
Salvi, Flavia
Liberati, Anna Marina
Gaidano, Gianluca
Bottelli, Chiara
Rossini, Bernardo
Perticone, Sonia
De Masi, Pasqualina
Ladetto, Marco
Ciccone, Giovannino
Palumbo, Antonio
Rossi, Giuseppe
Vitolo, Umberto
HAEMATOLOGICA, 2013, 98 (11) : 1732 - 1738

← 1 2 3 4 5 →