Base/B 2pin 2-Mediated Iodofluoroalkylation of Alkynes and Alkenes

被引：4

作者：

Wu, Jianglong ^{[1
]}

Wang, Chenyu ^{[1
]}

Wang, Zhongjie ^{[1
]}

Li, Hongjun ^{[1
]}

Liu, Ruyan ^{[1
]}

Wang, Yan ^{[1
]}

Zhou, Pengsheng ^{[1
]}

Li, Dianjun ^{[1
]}

Yang, Jinhui ^{[1
]}

机构：

[1] Ningxia Univ, Coll Chem & Chem Engn, State Key Lab High efficiency Utilizat Coal & Gre, Yinchuan 750021, Ningxia, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2022年 / 54卷 / 13期

基金：

中国国家自然科学基金;

关键词：

iodofluoroalkylation; alkynes; alkenes; ethyl 2,2-difluoro-2-iodoacetate; hydrodifluoroalkylation; TRANSFER RADICAL-ADDITION; SELECTIVE DIFLUOROALKYLATION; CARBOXYLIC-ACIDS; FLUORINE; FLUOROALKYLATION; IODIDES; TRIFLUOROMETHYLATION; HYDROBORATION; 1,2-ADDITION; BORYLATION;

D O I：

10.1055/a-1747-5457

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A base/B(2)pin(2)-mediated iodofluoroalkylation of alkynes and a part of alkenes, using ethyl difluoroiodoacetate (ICF2CO2Et) or ICnF2n+1 (n = 3, 4, 6) as difluoroacetylating or perfluoroalkylating reagent, is disclosed. The reaction proceeds under mild conditions, and iododifluoroalkylation, hydrodifluoroalkylation and several perfluoroalkylation products were generated from alkynes or alkenes. Notably, this methodology provides a simple access to difluoroalkylated and perfluoroalkylated organic compounds starting from simple alkynes or alkenes.

引用

页码：3055 / 3068

页数：14

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