Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast

被引:61
|
作者
Honma, N
Takubo, K
Akiyama, F
Sawabe, M
Arai, T
Younes, M
Kasumi, F
Sakamoto, G
机构
[1] Tokyo Metropolitan Inst Gerontol, Human Tissue Res Grp, Itabashi Ku, Tokyo 1730015, Japan
[2] Tokyo Metropolitan Geriatr Med Ctr, Dept Pathol, Tokyo, Japan
[3] Japanese Fdn Canc Res, Inst Canc, Dept Breast Pathol, Tokyo 170, Japan
[4] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA
[5] Canc Inst Hosp, Dept Breast Surg, Tokyo, Japan
关键词
androgen receptor; apocrine carcinoma; bcl-2; breast; gross cystic disease fluid protein-15 (GCDFP-15); HER2; Nottingham Prognostic Index (NPI); oestrogen receptor; progesterone receptor;
D O I
10.1111/j.1365-2559.2005.02181.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Aims: Apocrine carcinoma of the breast is typically, though not always, positive for gross cystic disease fluid protein-15 (GCDFP-15). In order to clarify the clinical significance of GCDFP-15 in apocrine carcinomas, GCDFP-15 expression was examined in apocrine carcinomas of different stages and compared with clinicopathological factors. Apocrine lesions reportedly exhibit an unusual immunohistochemical status, expressing androgen receptors (AR) instead of oestrogen receptors (ER), progesterone receptors (PR), or bcl-2. Their expression was also examined. Methods and results: Fifty-two apocrine carcinomas were examined immunohistochemically. Thirty-nine (75%) and 29 (56%) were positive for GCDFP-15 and AR, respectively. GCDFP-15 positivity was significantly lower in infiltrating carcinomas than intraductal carcinomas (P = 0.0111). In infiltrating carcinomas, GCDFP-15 positivity was significantly low in tumours >= 15 mm (P = 0.0005) and node-positive tumours (P = 0.0004). Similar phenomena were observed for AR. Rare cases were positive for ER (3.8%), PR (5.8%), and bcl-2 (1.9%). Conclusions: GCDFP-15 positivity is transient and should not be considered a definitive marker of apocrine carcinomas. Cases which have apocrine features but lack GCDFP-15 expression should rather be considered as advanced apocrine carcinomas. ER/PR/bcl-2 negativity will sometimes be helpful to confirm the diagnosis of apocrine carcinoma, because it is more consistent than GCDFP-15/AR positivity.
引用
收藏
页码:195 / 201
页数:7
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