A randomized, double-blind, placebo-controlled study of oral hydrolytic enzymes in relapsing multiple sclerosis

被引：13
|
作者：
Baumhackl, U
Kappos, L
Radue, EW
Freitag, P
Guseo, A
Daumer, M
Mertin, J
机构：
[1] Cent Clin, Dept Neurol, A-3100 St Polten, Austria
[2] Univ Basel Hosp, MS MRI Evaluat Ctr, CH-4031 Basel, Switzerland
[3] Cent Hosp Szekesfehervar, Dept Neurol, Szekesfehervar, Hungary
[4] Univ Munich, Inst Stat, Munich, Germany
[5] Clin Bad Windsheim, Dept Neurol, Windsheim, Germany
来源：
MULTIPLE SCLEROSIS JOURNAL | 2005年 / 11卷 / 02期
关键词：
hydrolytic enzymes; multiple sclerosis; therapy;
D O I：
10.1191/1352458505ms1132oa
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Oral administration of hydrolytic enzymes (HE), such as bromelain, trypsin and rutosid, may have beneficial effects on the clinical course of neurological symptoms related to multiple sclerosis (MS). This is supported by a complete protection by HE from experimental allergic encephalomyelitis, an animal model related to MS. Three hundred and one patients with relapsing MS were enrolled in a double-blind, placebo-controlled trial. No treatment effect between the placebo and the HE groups was found either for clinical or MRI parameters.
引用
收藏
页码：166 / 168
页数：3
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