A randomized, double-blind, placebo-controlled study of oral hydrolytic enzymes in relapsing multiple sclerosis

被引：13
|
作者：
Baumhackl, U
Kappos, L
Radue, EW
Freitag, P
Guseo, A
Daumer, M
Mertin, J
机构：
[1] Cent Clin, Dept Neurol, A-3100 St Polten, Austria
[2] Univ Basel Hosp, MS MRI Evaluat Ctr, CH-4031 Basel, Switzerland
[3] Cent Hosp Szekesfehervar, Dept Neurol, Szekesfehervar, Hungary
[4] Univ Munich, Inst Stat, Munich, Germany
[5] Clin Bad Windsheim, Dept Neurol, Windsheim, Germany
来源：
MULTIPLE SCLEROSIS JOURNAL | 2005年 / 11卷 / 02期
关键词：
hydrolytic enzymes; multiple sclerosis; therapy;
D O I：
10.1191/1352458505ms1132oa
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Oral administration of hydrolytic enzymes (HE), such as bromelain, trypsin and rutosid, may have beneficial effects on the clinical course of neurological symptoms related to multiple sclerosis (MS). This is supported by a complete protection by HE from experimental allergic encephalomyelitis, an animal model related to MS. Three hundred and one patients with relapsing MS were enrolled in a double-blind, placebo-controlled trial. No treatment effect between the placebo and the HE groups was found either for clinical or MRI parameters.
引用
收藏
页码：166 / 168
页数：3
相关论文
共 50 条
  • [1] A randomised, double-blind, placebo-controlled study of fluoxetine for relapsing multiple sclerosis
    Mostert, I. P.
    Admilaal-Behlou, E.
    Hoogduin, I. M.
    Luyetidijk, J.
    Heersema, D. J.
    van Buchem, M. A.
    de Keyser, J.
    [J]. MULTIPLE SCLEROSIS, 2007, 13 : S25 - S26
  • [2] Acyclovir treatment of relapsing-remitting multiple sclerosis - A randomized, placebo-controlled, double-blind study
    Lycke, J
    Svennerholm, B
    Hjelmquist, E
    Frisen, L
    Badr, G
    Andersson, M
    Vahlne, A
    Andersen, O
    [J]. JOURNAL OF NEUROLOGY, 1996, 243 (03) : 214 - 224
  • [3] A double-blind, placebo-controlled, randomized trial of cladribine in relapsing-remitting multiple sclerosis
    Romine, JS
    Sipe, JC
    Koziol, JA
    Zyroff, J
    Beutler, E
    [J]. PROCEEDINGS OF THE ASSOCIATION OF AMERICAN PHYSICIANS, 1999, 111 (01) : 35 - 44
  • [4] Efficacy and Safety of Tabalumab in Patients with Relapsing-Remitting Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Study
    Silk, Maria
    Nantz, Eric
    [J]. NEUROLOGY, 2018, 90
  • [5] Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis
    Ebers, GC
    Rice, G
    Lesaux, J
    Paty, D
    Oger, J
    Li, DKB
    Beall, S
    Devonshire, V
    Hashimoto, S
    Hooge, J
    Kastrukoff, L
    Krieger, C
    Mezei, M
    Seland, P
    Vorobeychi, G
    Morrison, W
    Nelson, J
    Freedman, MS
    Chrisie, S
    Nelson, R
    Rabinovitch, H
    Freedman, C
    Hartung, HP
    Rieckmann, P
    Archelos, J
    Jung, S
    Weilbach, F
    Flachenecke, P
    Sauer, J
    Hommes, O
    Jongen, P
    Brouwer, S
    McLeod, J
    Pollard, J
    Ng, R
    Sandberg-Wollheim, M
    Källén, K
    Nilsson, P
    Ekberg, R
    Lundgren, A
    Jadbäck, G
    Wikström, J
    Multanen, J
    Valjakka, M
    Carton, H
    Lissoir, F
    Declerq, I
    Vieren, M
    Peeters, E
    Dubois, B
    [J]. LANCET, 1998, 352 (9139): : 1498 - 1504
  • [6] A double-blind, placebo-controlled, multicentre study to evaluate dirucotide in relapsing-remitting multiple sclerosis
    Selmaj, K.
    Verco, T.
    Ossanna, M.
    Nilsson, M.
    Ferenczi, L.
    Chappell, A.
    Arfors, L.
    [J]. MULTIPLE SCLEROSIS, 2009, 15 (09): : S235 - S235
  • [7] Effects of fluoxetine on disease activity in relapsing multiple sclerosis: a double-blind, placebo-controlled, exploratory study
    Mostert, J. P.
    Admiraal-Behloul, F.
    Hoogduin, J. M.
    Luyendijk, J.
    Heersema, D. J.
    van Buchem, M. A.
    De Keyser, J.
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2008, 79 (09): : 1027 - 1031
  • [8] Ginseng in the treatment of fatigue in multiple sclerosis: a randomized, placebo-controlled, double-blind pilot study
    Etemadifar, Masoud
    Sayahi, Farnaz
    Abtahi, Seyed-Hossein
    Shemshaki, Hamidreza
    Dorooshi, Gholam-Ali
    Goodarzi, Mohammad
    Akbari, Mojtaba
    Fereidan-Esfahani, Mahboobeh
    [J]. INTERNATIONAL JOURNAL OF NEUROSCIENCE, 2013, 123 (07) : 480 - 486
  • [9] Ginseng in the treatment of fatigue in multiple sclerosis: a randomized, placebo-controlled, double-blind pilot study
    Fereidan-Esfahani, Mahboobeh
    Etemadifar, Masoud
    Sayahi, Farnaz
    Abtahi, Seyed-Hossein
    [J]. MULTIPLE SCLEROSIS JOURNAL, 2014, 20 (07) : 936 - 936
  • [10] HYPERBARIC-OXYGEN IN MULTIPLE-SCLEROSIS - A DOUBLE-BLIND RANDOMIZED PLACEBO-CONTROLLED STUDY
    CONFAVREUX, C
    MATHIEU, C
    CHACORNAC, R
    AIMARD, G
    DEVIC, M
    [J]. PRESSE MEDICALE, 1986, 15 (28): : 1319 - 1322
12345