Cathepsin G Degrades Staphylococcus aureus Biofilms

被引：11

作者：

Kavanaugh, Jeffrey S. ^{[1
]}

Leidal, Kevin G. ^{[2
]}

Nauseef, William M. ^{[2
]}

Horswill, Alexander R. ^{[1
,3
]}

机构：

[1] Univ Colorado, Dept Immunol & Microbiol, Anschutz Med Campus, Aurora, CO USA

[2] Univ Iowa, Dept Med, Inflammat Program, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA

[3] Eastern Colorado Hlth Care Syst, Dept Vet Affairs, Denver, CO USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2021年 / 223卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Staphylococcus aureus; biofilm; polymorphonuclear leukocytes; cathepsin G; PHAGOCYTOSIS; NEUTROPHILS;

D O I：

10.1093/infdis/jiaa612

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Polymorphonuclear leukocytes (PMN) phagocytose and kill individual bacteria but are far less efficient when challenged with bacterial aggregates. Consequently, growth within a biofilm affords Staphylococcus aureus some protection but PMN penetrate S. aureus biofilms and phagocytose bacteria, suggesting that enzymes released through neutrophil degranulation degrade biofilms into fragments small enough for phagocytosis. Here we show that the capacity of PMN to invade biofilms depended largely on the activity of secreted cathepsin G.

引用

页码：1865 / 1869

页数：5

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